Repression of Smoothened by Patched-Dependent (Pro-)Vitamin D3 Secretion

The developmentally important hedgehog (Hh) pathway is activated by binding of Hh to patched (Ptch1), releasing smoothened (Smo) and the downstream transcription factor glioma associated (Gli) from inhibition. The mechanism behind Ptch1-dependent Smo inhibition remains unresolved. We now show that b...

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Detalles Bibliográficos
Autores principales: Bijlsma, Maarten F, Spek, C. Arnold, Zivkovic, Danica, van de Water, Sandra, Rezaee, Farhad, Peppelenbosch, Maikel P
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2006
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1502141/
https://www.ncbi.nlm.nih.gov/pubmed/16895439
http://dx.doi.org/10.1371/journal.pbio.0040232

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1502141/
https://www.ncbi.nlm.nih.gov/pubmed/16895439
http://dx.doi.org/10.1371/journal.pbio.0040232

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