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Repression of Smoothened by Patched-Dependent (Pro-)Vitamin D3 Secretion
The developmentally important hedgehog (Hh) pathway is activated by binding of Hh to patched (Ptch1), releasing smoothened (Smo) and the downstream transcription factor glioma associated (Gli) from inhibition. The mechanism behind Ptch1-dependent Smo inhibition remains unresolved. We now show that b...
| Autores principales: | , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2006
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1502141/ https://www.ncbi.nlm.nih.gov/pubmed/16895439 http://dx.doi.org/10.1371/journal.pbio.0040232 |