Evolution of the initiating enzymes of the complement system

Analysis of the human MASP-1/3 gene, which encodes two proteases of the lectin-triggered complement cascade, has revealed alternatively used serine-protease-encoding regions for the gene's two protein products. Phylogenetic studies indicate that one arose by retrotransposition early in vertebra...

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Detalles Bibliográficos
Autores principales: Nonaka, Masaru, Miyazawa, Seita
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2002
Materias:
Minireview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC150455/
https://www.ncbi.nlm.nih.gov/pubmed/11806831
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author Nonaka, Masaru
Miyazawa, Seita
author_facet Nonaka, Masaru
Miyazawa, Seita
author_sort Nonaka, Masaru
collection PubMed
description Analysis of the human MASP-1/3 gene, which encodes two proteases of the lectin-triggered complement cascade, has revealed alternatively used serine-protease-encoding regions for the gene's two protein products. Phylogenetic studies indicate that one arose by retrotransposition early in vertebrate evolution, supporting the idea that the lectin branch of the complement cascade arose earlier than the 'classical' pathway.
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spelling pubmed-1504552003-03-07 Evolution of the initiating enzymes of the complement system Nonaka, Masaru Miyazawa, Seita Genome Biol Minireview Analysis of the human MASP-1/3 gene, which encodes two proteases of the lectin-triggered complement cascade, has revealed alternatively used serine-protease-encoding regions for the gene's two protein products. Phylogenetic studies indicate that one arose by retrotransposition early in vertebrate evolution, supporting the idea that the lectin branch of the complement cascade arose earlier than the 'classical' pathway. BioMed Central 2002 2001-12-14 /pmc/articles/PMC150455/ /pubmed/11806831 Text en Copyright © 2001 BioMed Central Ltd
spellingShingle Minireview
Nonaka, Masaru
Miyazawa, Seita
Evolution of the initiating enzymes of the complement system
title Evolution of the initiating enzymes of the complement system
title_full Evolution of the initiating enzymes of the complement system
title_fullStr Evolution of the initiating enzymes of the complement system
title_full_unstemmed Evolution of the initiating enzymes of the complement system
title_short Evolution of the initiating enzymes of the complement system
title_sort evolution of the initiating enzymes of the complement system
topic Minireview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC150455/
https://www.ncbi.nlm.nih.gov/pubmed/11806831
work_keys_str_mv AT nonakamasaru evolutionoftheinitiatingenzymesofthecomplementsystem
AT miyazawaseita evolutionoftheinitiatingenzymesofthecomplementsystem

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