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Free radical theory of autoimmunity
BACKGROUND: Despite great advances in clinical oncology, the molecular mechanisms underlying the failure of chemotherapeutic intervention in treating lymphoproliferative and related disorders are not well understood. HYPOTHESIS: A hypothetical scheme to explain the damage induced by chemotherapy and...
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2006
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1508139/ https://www.ncbi.nlm.nih.gov/pubmed/16759382 http://dx.doi.org/10.1186/1742-4682-3-22 |
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author | Kannan, Subburaj |
author_facet | Kannan, Subburaj |
author_sort | Kannan, Subburaj |
collection | PubMed |
description | BACKGROUND: Despite great advances in clinical oncology, the molecular mechanisms underlying the failure of chemotherapeutic intervention in treating lymphoproliferative and related disorders are not well understood. HYPOTHESIS: A hypothetical scheme to explain the damage induced by chemotherapy and associated chronic oxidative stress is proposed on the basis of published literature, experimental data and anecdotal observations. Brief accounts of multidrug resistance, lymphoid malignancy, the cellular and molecular basis of autoimmunity and chronic oxidative stress are assembled to form a basis for the hypothesis and to indicate the likelihood that it is valid in vivo. CONCLUSION: The argument set forward in this article suggests a possible mechanism for the development of autoimmunity. According to this view, the various sorts of damage induced by chemotherapy have a role in the pattern of drug resistance, which is associated with the initiation of autoimmunity. |
format | Text |
id | pubmed-1508139 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2006 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-15081392006-07-15 Free radical theory of autoimmunity Kannan, Subburaj Theor Biol Med Model Research BACKGROUND: Despite great advances in clinical oncology, the molecular mechanisms underlying the failure of chemotherapeutic intervention in treating lymphoproliferative and related disorders are not well understood. HYPOTHESIS: A hypothetical scheme to explain the damage induced by chemotherapy and associated chronic oxidative stress is proposed on the basis of published literature, experimental data and anecdotal observations. Brief accounts of multidrug resistance, lymphoid malignancy, the cellular and molecular basis of autoimmunity and chronic oxidative stress are assembled to form a basis for the hypothesis and to indicate the likelihood that it is valid in vivo. CONCLUSION: The argument set forward in this article suggests a possible mechanism for the development of autoimmunity. According to this view, the various sorts of damage induced by chemotherapy have a role in the pattern of drug resistance, which is associated with the initiation of autoimmunity. BioMed Central 2006-06-07 /pmc/articles/PMC1508139/ /pubmed/16759382 http://dx.doi.org/10.1186/1742-4682-3-22 Text en Copyright © 2006 Kannan; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Kannan, Subburaj Free radical theory of autoimmunity |
title | Free radical theory of autoimmunity |
title_full | Free radical theory of autoimmunity |
title_fullStr | Free radical theory of autoimmunity |
title_full_unstemmed | Free radical theory of autoimmunity |
title_short | Free radical theory of autoimmunity |
title_sort | free radical theory of autoimmunity |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1508139/ https://www.ncbi.nlm.nih.gov/pubmed/16759382 http://dx.doi.org/10.1186/1742-4682-3-22 |
work_keys_str_mv | AT kannansubburaj freeradicaltheoryofautoimmunity |