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Mechanisms of Neuronal Death in Synucleinopathy

α-synuclein is a key molecule in the pathogenesis of synucleinopathy including Parkinson's disease and multiple system atrophy. In this mini-review, we mainly focus on recent data obtained from cellular models of synucleinopathy and discuss the possible mechanisms of neurodegeneration. Recent p...

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Autores principales: Takeda, Atsushi, Hasegawa, Takafumi, Matsuzaki-Kobayashi, Michiko, Sugeno, Naoto, Kikuchi, Akio, Itoyama, Yasuto, Furukawa, Katsutoshi
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1510951/
https://www.ncbi.nlm.nih.gov/pubmed/17047300
http://dx.doi.org/10.1155/JBB/2006/19365
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author Takeda, Atsushi
Hasegawa, Takafumi
Matsuzaki-Kobayashi, Michiko
Sugeno, Naoto
Kikuchi, Akio
Itoyama, Yasuto
Furukawa, Katsutoshi
author_facet Takeda, Atsushi
Hasegawa, Takafumi
Matsuzaki-Kobayashi, Michiko
Sugeno, Naoto
Kikuchi, Akio
Itoyama, Yasuto
Furukawa, Katsutoshi
author_sort Takeda, Atsushi
collection PubMed
description α-synuclein is a key molecule in the pathogenesis of synucleinopathy including Parkinson's disease and multiple system atrophy. In this mini-review, we mainly focus on recent data obtained from cellular models of synucleinopathy and discuss the possible mechanisms of neurodegeneration. Recent progress suggests that the aggregate formation of α-synuclein is cytoprotective and that its precursor oligomer (protofibril) may be cytotoxic. The catechol-derived quinones are the candidate molecules that facilitate the oligomer formation of α-synuclein. Furthermore, the cellular membranes are shown to be the primary targets injured by mutant α-synucleins, and the mitochondrial dysfunction seems to be an initial step in the neuronal death.
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spelling pubmed-15109512006-08-31 Mechanisms of Neuronal Death in Synucleinopathy Takeda, Atsushi Hasegawa, Takafumi Matsuzaki-Kobayashi, Michiko Sugeno, Naoto Kikuchi, Akio Itoyama, Yasuto Furukawa, Katsutoshi J Biomed Biotechnol Mini-Review Article α-synuclein is a key molecule in the pathogenesis of synucleinopathy including Parkinson's disease and multiple system atrophy. In this mini-review, we mainly focus on recent data obtained from cellular models of synucleinopathy and discuss the possible mechanisms of neurodegeneration. Recent progress suggests that the aggregate formation of α-synuclein is cytoprotective and that its precursor oligomer (protofibril) may be cytotoxic. The catechol-derived quinones are the candidate molecules that facilitate the oligomer formation of α-synuclein. Furthermore, the cellular membranes are shown to be the primary targets injured by mutant α-synucleins, and the mitochondrial dysfunction seems to be an initial step in the neuronal death. Hindawi Publishing Corporation 2006 2006 /pmc/articles/PMC1510951/ /pubmed/17047300 http://dx.doi.org/10.1155/JBB/2006/19365 Text en Copyright © 2006 Atsushi Takeda et al. This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Mini-Review Article
Takeda, Atsushi
Hasegawa, Takafumi
Matsuzaki-Kobayashi, Michiko
Sugeno, Naoto
Kikuchi, Akio
Itoyama, Yasuto
Furukawa, Katsutoshi
Mechanisms of Neuronal Death in Synucleinopathy
title Mechanisms of Neuronal Death in Synucleinopathy
title_full Mechanisms of Neuronal Death in Synucleinopathy
title_fullStr Mechanisms of Neuronal Death in Synucleinopathy
title_full_unstemmed Mechanisms of Neuronal Death in Synucleinopathy
title_short Mechanisms of Neuronal Death in Synucleinopathy
title_sort mechanisms of neuronal death in synucleinopathy
topic Mini-Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1510951/
https://www.ncbi.nlm.nih.gov/pubmed/17047300
http://dx.doi.org/10.1155/JBB/2006/19365
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