An integrated computational pipeline and database to support whole-genome sequence annotation

We describe here our experience in annotating the Drosophila melanogaster genome sequence, in the course of which we developed several new open-source software tools and a database schema to support large-scale genome annotation. We have developed these into an integrated and reusable software syste...

Descripción completa

Detalles Bibliográficos
Autores principales: Mungall, CJ, Misra, S, Berman, BP, Carlson, J, Frise, E, Harris, N, Marshall, B, Shu, S, Kaminker, JS, Prochnik, SE, Smith, CD, Smith, E, Tupy, JL, Wiel, C, Rubin, GM, Lewis, SE
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2002
Materias:
Software
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC151183/
https://www.ncbi.nlm.nih.gov/pubmed/12537570
http://dx.doi.org/10.1186/gb-2002-3-12-research0081
Descripción
Sumario:We describe here our experience in annotating the Drosophila melanogaster genome sequence, in the course of which we developed several new open-source software tools and a database schema to support large-scale genome annotation. We have developed these into an integrated and reusable software system for whole-genome annotation. The key contributions to overall annotation quality are the marshalling of high-quality sequences for alignments and the design of a system with an adaptable and expandable flexible architecture.

Ejemplares similares