An integrated computational pipeline and database to support whole-genome sequence annotation

We describe here our experience in annotating the Drosophila melanogaster genome sequence, in the course of which we developed several new open-source software tools and a database schema to support large-scale genome annotation. We have developed these into an integrated and reusable software syste...

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Detalles Bibliográficos
Autores principales: Mungall, CJ, Misra, S, Berman, BP, Carlson, J, Frise, E, Harris, N, Marshall, B, Shu, S, Kaminker, JS, Prochnik, SE, Smith, CD, Smith, E, Tupy, JL, Wiel, C, Rubin, GM, Lewis, SE
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2002
Materias:
Software
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC151183/
https://www.ncbi.nlm.nih.gov/pubmed/12537570
http://dx.doi.org/10.1186/gb-2002-3-12-research0081
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author Mungall, CJ
Misra, S
Berman, BP
Carlson, J
Frise, E
Harris, N
Marshall, B
Shu, S
Kaminker, JS
Prochnik, SE
Smith, CD
Smith, E
Tupy, JL
Wiel, C
Rubin, GM
Lewis, SE
author_facet Mungall, CJ
Misra, S
Berman, BP
Carlson, J
Frise, E
Harris, N
Marshall, B
Shu, S
Kaminker, JS
Prochnik, SE
Smith, CD
Smith, E
Tupy, JL
Wiel, C
Rubin, GM
Lewis, SE
author_sort Mungall, CJ
collection PubMed
description We describe here our experience in annotating the Drosophila melanogaster genome sequence, in the course of which we developed several new open-source software tools and a database schema to support large-scale genome annotation. We have developed these into an integrated and reusable software system for whole-genome annotation. The key contributions to overall annotation quality are the marshalling of high-quality sequences for alignments and the design of a system with an adaptable and expandable flexible architecture.
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spelling pubmed-1511832003-03-13 An integrated computational pipeline and database to support whole-genome sequence annotation Mungall, CJ Misra, S Berman, BP Carlson, J Frise, E Harris, N Marshall, B Shu, S Kaminker, JS Prochnik, SE Smith, CD Smith, E Tupy, JL Wiel, C Rubin, GM Lewis, SE Genome Biol Software We describe here our experience in annotating the Drosophila melanogaster genome sequence, in the course of which we developed several new open-source software tools and a database schema to support large-scale genome annotation. We have developed these into an integrated and reusable software system for whole-genome annotation. The key contributions to overall annotation quality are the marshalling of high-quality sequences for alignments and the design of a system with an adaptable and expandable flexible architecture. BioMed Central 2002 2002-12-23 /pmc/articles/PMC151183/ /pubmed/12537570 http://dx.doi.org/10.1186/gb-2002-3-12-research0081 Text en Copyright © 2002 Mungall et al., licensee BioMed Central Ltd
spellingShingle Software
Mungall, CJ
Misra, S
Berman, BP
Carlson, J
Frise, E
Harris, N
Marshall, B
Shu, S
Kaminker, JS
Prochnik, SE
Smith, CD
Smith, E
Tupy, JL
Wiel, C
Rubin, GM
Lewis, SE
An integrated computational pipeline and database to support whole-genome sequence annotation
title An integrated computational pipeline and database to support whole-genome sequence annotation
title_full An integrated computational pipeline and database to support whole-genome sequence annotation
title_fullStr An integrated computational pipeline and database to support whole-genome sequence annotation
title_full_unstemmed An integrated computational pipeline and database to support whole-genome sequence annotation
title_short An integrated computational pipeline and database to support whole-genome sequence annotation
title_sort integrated computational pipeline and database to support whole-genome sequence annotation
topic Software
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC151183/
https://www.ncbi.nlm.nih.gov/pubmed/12537570
http://dx.doi.org/10.1186/gb-2002-3-12-research0081
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