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Sp1- and Krüppel-like transcription factors

Sp1-like proteins and Krüppel-like factors (KLFs) are highly related zinc-finger proteins that are important components of the eukaryotic cellular transcriptional machinery. By regulating the expression of a large number of genes that have GC-rich promoters, Sp1-like/KLF transcription regulators may...

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Autores principales: Kaczynski, Joanna, Cook, Tiffany, Urrutia, Raul
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2003
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC151296/
https://www.ncbi.nlm.nih.gov/pubmed/12620113
http://dx.doi.org/10.1186/gb-2003-4-2-206
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author Kaczynski, Joanna
Cook, Tiffany
Urrutia, Raul
author_facet Kaczynski, Joanna
Cook, Tiffany
Urrutia, Raul
author_sort Kaczynski, Joanna
collection PubMed
description Sp1-like proteins and Krüppel-like factors (KLFs) are highly related zinc-finger proteins that are important components of the eukaryotic cellular transcriptional machinery. By regulating the expression of a large number of genes that have GC-rich promoters, Sp1-like/KLF transcription regulators may take part in virtually all facets of cellular function, including cell proliferation, apoptosis, differentiation, and neoplastic transformation. Individual members of the Sp1-like/KLF family can function as activators or repressors depending on which promoter they bind and the coregulators with which they interact. A long-standing research aim has been to define the mechanisms by which Sp1-like factors and KLFs regulate gene expression and cellular function in a cell- and promoter-specific manner. Most members of this family have been identified in mammals, with at least 21 Sp1-like/KLF proteins encoded in the human genome, and members are also found in frogs, worms and flies. Sp1-like/KLF proteins have highly conserved carboxy-terminal zinc-finger domains that function in DNA binding. The amino terminus, containing the transcription activation domain, can vary significantly between family members.
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spelling pubmed-1512962003-03-13 Sp1- and Krüppel-like transcription factors Kaczynski, Joanna Cook, Tiffany Urrutia, Raul Genome Biol Protein Family Review Sp1-like proteins and Krüppel-like factors (KLFs) are highly related zinc-finger proteins that are important components of the eukaryotic cellular transcriptional machinery. By regulating the expression of a large number of genes that have GC-rich promoters, Sp1-like/KLF transcription regulators may take part in virtually all facets of cellular function, including cell proliferation, apoptosis, differentiation, and neoplastic transformation. Individual members of the Sp1-like/KLF family can function as activators or repressors depending on which promoter they bind and the coregulators with which they interact. A long-standing research aim has been to define the mechanisms by which Sp1-like factors and KLFs regulate gene expression and cellular function in a cell- and promoter-specific manner. Most members of this family have been identified in mammals, with at least 21 Sp1-like/KLF proteins encoded in the human genome, and members are also found in frogs, worms and flies. Sp1-like/KLF proteins have highly conserved carboxy-terminal zinc-finger domains that function in DNA binding. The amino terminus, containing the transcription activation domain, can vary significantly between family members. BioMed Central 2003 2003-02-03 /pmc/articles/PMC151296/ /pubmed/12620113 http://dx.doi.org/10.1186/gb-2003-4-2-206 Text en Copyright © 2003 BioMed Central Ltd
spellingShingle Protein Family Review
Kaczynski, Joanna
Cook, Tiffany
Urrutia, Raul
Sp1- and Krüppel-like transcription factors
title Sp1- and Krüppel-like transcription factors
title_full Sp1- and Krüppel-like transcription factors
title_fullStr Sp1- and Krüppel-like transcription factors
title_full_unstemmed Sp1- and Krüppel-like transcription factors
title_short Sp1- and Krüppel-like transcription factors
title_sort sp1- and krüppel-like transcription factors
topic Protein Family Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC151296/
https://www.ncbi.nlm.nih.gov/pubmed/12620113
http://dx.doi.org/10.1186/gb-2003-4-2-206
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