A tale of two estrogen receptors (ERs): how differential ER-estrogen responsive element interactions contribute to subtype-specific transcriptional responses

The interaction of ERα and ERβ with ERE constitutes the initial step in the canonical nuclear E2 signaling in which E2-ERβ is a weaker transactivator than E2-ERα. This perspective summarizes recent findings to discuss potential mechanisms that contribute to ER subtype-specific transcriptional respon...

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Detalles Bibliográficos
Autores principales: Huang, Jing, Li, Xiaodong, Qiao, Tao, Bambara, Robert A., Hilf, Russell, Muyan, Mesut
Formato: Texto
Lenguaje:English
Publicado: The Nuclear Receptor Signaling Atlas 2006
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1513069/
https://www.ncbi.nlm.nih.gov/pubmed/16862221
http://dx.doi.org/10.1621/nrs.04015
Descripción
Sumario:The interaction of ERα and ERβ with ERE constitutes the initial step in the canonical nuclear E2 signaling in which E2-ERβ is a weaker transactivator than E2-ERα. This perspective summarizes recent findings to discuss potential mechanisms that contribute to ER subtype-specific transcriptional responses.

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