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Secular trends of antimicrobial resistance of blood isolates in a newly founded Greek hospital

BACKGROUND: Antimicrobial resistance is one of the most challenging issues in modern medicine. METHODS: We evaluated the secular trends of the relative frequency of blood isolates and of the pattern of their in vitro antimicrobial susceptibility in our hospital during the last four and a half years....

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Autores principales: Falagas, Matthew E, Kasiakou, Sofia K, Nikita, Dimitra, Morfou, Panayiota, Georgoulias, George, Rafailidis, Petros I
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1513235/
https://www.ncbi.nlm.nih.gov/pubmed/16776825
http://dx.doi.org/10.1186/1471-2334-6-99
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author Falagas, Matthew E
Kasiakou, Sofia K
Nikita, Dimitra
Morfou, Panayiota
Georgoulias, George
Rafailidis, Petros I
author_facet Falagas, Matthew E
Kasiakou, Sofia K
Nikita, Dimitra
Morfou, Panayiota
Georgoulias, George
Rafailidis, Petros I
author_sort Falagas, Matthew E
collection PubMed
description BACKGROUND: Antimicrobial resistance is one of the most challenging issues in modern medicine. METHODS: We evaluated the secular trends of the relative frequency of blood isolates and of the pattern of their in vitro antimicrobial susceptibility in our hospital during the last four and a half years. RESULTS: Overall, the data regarding the relative frequency of blood isolates in our newly founded hospital do not differ significantly from those of hospitals that are functioning for a much longer period of time. A noteworthy emerging problem is the increasing antimicrobial resistance of Gram-negative bacteria, mainly Acinetobacter baumannii and Klebsiella pneumoniae to various classes of antibiotics. Acinetobacter baumannii isolates showed an increase of resistance to amikacin (p = 0.019), ciprofloxacin (p = 0.001), imipenem (p < 0.001), and piperacillin/tazobactam (p = 0.01) between the first and second period of the study. CONCLUSION: An alarming increase of the antimicrobial resistance of Acinetobacter baumannii isolates has been noted during our study.
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spelling pubmed-15132352006-07-20 Secular trends of antimicrobial resistance of blood isolates in a newly founded Greek hospital Falagas, Matthew E Kasiakou, Sofia K Nikita, Dimitra Morfou, Panayiota Georgoulias, George Rafailidis, Petros I BMC Infect Dis Research Article BACKGROUND: Antimicrobial resistance is one of the most challenging issues in modern medicine. METHODS: We evaluated the secular trends of the relative frequency of blood isolates and of the pattern of their in vitro antimicrobial susceptibility in our hospital during the last four and a half years. RESULTS: Overall, the data regarding the relative frequency of blood isolates in our newly founded hospital do not differ significantly from those of hospitals that are functioning for a much longer period of time. A noteworthy emerging problem is the increasing antimicrobial resistance of Gram-negative bacteria, mainly Acinetobacter baumannii and Klebsiella pneumoniae to various classes of antibiotics. Acinetobacter baumannii isolates showed an increase of resistance to amikacin (p = 0.019), ciprofloxacin (p = 0.001), imipenem (p < 0.001), and piperacillin/tazobactam (p = 0.01) between the first and second period of the study. CONCLUSION: An alarming increase of the antimicrobial resistance of Acinetobacter baumannii isolates has been noted during our study. BioMed Central 2006-06-15 /pmc/articles/PMC1513235/ /pubmed/16776825 http://dx.doi.org/10.1186/1471-2334-6-99 Text en Copyright © 2006 Falagas et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Falagas, Matthew E
Kasiakou, Sofia K
Nikita, Dimitra
Morfou, Panayiota
Georgoulias, George
Rafailidis, Petros I
Secular trends of antimicrobial resistance of blood isolates in a newly founded Greek hospital
title Secular trends of antimicrobial resistance of blood isolates in a newly founded Greek hospital
title_full Secular trends of antimicrobial resistance of blood isolates in a newly founded Greek hospital
title_fullStr Secular trends of antimicrobial resistance of blood isolates in a newly founded Greek hospital
title_full_unstemmed Secular trends of antimicrobial resistance of blood isolates in a newly founded Greek hospital
title_short Secular trends of antimicrobial resistance of blood isolates in a newly founded Greek hospital
title_sort secular trends of antimicrobial resistance of blood isolates in a newly founded greek hospital
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1513235/
https://www.ncbi.nlm.nih.gov/pubmed/16776825
http://dx.doi.org/10.1186/1471-2334-6-99
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