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Secular trends of antimicrobial resistance of blood isolates in a newly founded Greek hospital
BACKGROUND: Antimicrobial resistance is one of the most challenging issues in modern medicine. METHODS: We evaluated the secular trends of the relative frequency of blood isolates and of the pattern of their in vitro antimicrobial susceptibility in our hospital during the last four and a half years....
Autores principales: | , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2006
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1513235/ https://www.ncbi.nlm.nih.gov/pubmed/16776825 http://dx.doi.org/10.1186/1471-2334-6-99 |
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author | Falagas, Matthew E Kasiakou, Sofia K Nikita, Dimitra Morfou, Panayiota Georgoulias, George Rafailidis, Petros I |
author_facet | Falagas, Matthew E Kasiakou, Sofia K Nikita, Dimitra Morfou, Panayiota Georgoulias, George Rafailidis, Petros I |
author_sort | Falagas, Matthew E |
collection | PubMed |
description | BACKGROUND: Antimicrobial resistance is one of the most challenging issues in modern medicine. METHODS: We evaluated the secular trends of the relative frequency of blood isolates and of the pattern of their in vitro antimicrobial susceptibility in our hospital during the last four and a half years. RESULTS: Overall, the data regarding the relative frequency of blood isolates in our newly founded hospital do not differ significantly from those of hospitals that are functioning for a much longer period of time. A noteworthy emerging problem is the increasing antimicrobial resistance of Gram-negative bacteria, mainly Acinetobacter baumannii and Klebsiella pneumoniae to various classes of antibiotics. Acinetobacter baumannii isolates showed an increase of resistance to amikacin (p = 0.019), ciprofloxacin (p = 0.001), imipenem (p < 0.001), and piperacillin/tazobactam (p = 0.01) between the first and second period of the study. CONCLUSION: An alarming increase of the antimicrobial resistance of Acinetobacter baumannii isolates has been noted during our study. |
format | Text |
id | pubmed-1513235 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2006 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-15132352006-07-20 Secular trends of antimicrobial resistance of blood isolates in a newly founded Greek hospital Falagas, Matthew E Kasiakou, Sofia K Nikita, Dimitra Morfou, Panayiota Georgoulias, George Rafailidis, Petros I BMC Infect Dis Research Article BACKGROUND: Antimicrobial resistance is one of the most challenging issues in modern medicine. METHODS: We evaluated the secular trends of the relative frequency of blood isolates and of the pattern of their in vitro antimicrobial susceptibility in our hospital during the last four and a half years. RESULTS: Overall, the data regarding the relative frequency of blood isolates in our newly founded hospital do not differ significantly from those of hospitals that are functioning for a much longer period of time. A noteworthy emerging problem is the increasing antimicrobial resistance of Gram-negative bacteria, mainly Acinetobacter baumannii and Klebsiella pneumoniae to various classes of antibiotics. Acinetobacter baumannii isolates showed an increase of resistance to amikacin (p = 0.019), ciprofloxacin (p = 0.001), imipenem (p < 0.001), and piperacillin/tazobactam (p = 0.01) between the first and second period of the study. CONCLUSION: An alarming increase of the antimicrobial resistance of Acinetobacter baumannii isolates has been noted during our study. BioMed Central 2006-06-15 /pmc/articles/PMC1513235/ /pubmed/16776825 http://dx.doi.org/10.1186/1471-2334-6-99 Text en Copyright © 2006 Falagas et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Falagas, Matthew E Kasiakou, Sofia K Nikita, Dimitra Morfou, Panayiota Georgoulias, George Rafailidis, Petros I Secular trends of antimicrobial resistance of blood isolates in a newly founded Greek hospital |
title | Secular trends of antimicrobial resistance of blood isolates in a newly founded Greek hospital |
title_full | Secular trends of antimicrobial resistance of blood isolates in a newly founded Greek hospital |
title_fullStr | Secular trends of antimicrobial resistance of blood isolates in a newly founded Greek hospital |
title_full_unstemmed | Secular trends of antimicrobial resistance of blood isolates in a newly founded Greek hospital |
title_short | Secular trends of antimicrobial resistance of blood isolates in a newly founded Greek hospital |
title_sort | secular trends of antimicrobial resistance of blood isolates in a newly founded greek hospital |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1513235/ https://www.ncbi.nlm.nih.gov/pubmed/16776825 http://dx.doi.org/10.1186/1471-2334-6-99 |
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