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Analysis of folylpoly-γ-glutamate synthetase gene expression in human B-precursor ALL and T-lineage ALL cells

BACKGROUND: Expression of folylpoly-γ-glutamate synthetase (FPGS) gene is two- to three-fold higher in B-precursor ALL (Bp- ALL) than in T-lineage ALL (T-ALL) and correlates with intracellular accumulation of methotrexate (MTX) polyglutamates and lymphoblast sensitivity to MTX. In this report, we in...

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Detalles Bibliográficos
Autores principales:	Leclerc, Guy J, Leclerc, Gilles M, Kinser, Ting Ting Hsieh, Barredo, Julio C
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2006
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1513244/ https://www.ncbi.nlm.nih.gov/pubmed/16707018 http://dx.doi.org/10.1186/1471-2407-6-132

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