Comparative genomic mapping of the bovine Fragile Histidine Triad (FHIT) tumour suppressor gene: characterization of a 2 Mb BAC contig covering the locus, complete annotation of the gene, analysis of cDNA and of physiological expression profiles

BACKGROUND: The Fragile Histidine Triad gene (FHIT) is an oncosuppressor implicated in many human cancers, including vesical tumors. FHIT is frequently hit by deletions caused by fragility at FRA3B, the most active of human common fragile sites, where FHIT lays. Vesical tumors affect also cattle, in...

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Detalles Bibliográficos
Autores principales: Uboldi, Cristina, Guidi, Elena, Roperto, Sante, Russo, Valeria, Roperto, Franco, Di Meo, Giulia Pia, Iannuzzi, Leopoldo, Floriot, Sandrine, Boussaha, Mekki, Eggen, André, Ferretti, Luca
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1513570/
https://www.ncbi.nlm.nih.gov/pubmed/16719907
http://dx.doi.org/10.1186/1471-2164-7-123

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