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Expression of constitutively active 4EBP-1 enhances p27(Kip1 )expression and inhibits proliferation of MCF7 breast cancer cells

BACKGROUND: Eukaryotic initiation factor 4E (eIF4E) is essential for cap-dependent initiation of translation. Cell proliferation is associated with increased activity of eIF4E and elevated expression of eIF4E leads to tumorigenic transformation. Many tumors express very high levels of eIF4E and this...

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Detalles Bibliográficos
Autores principales:	Jiang, Hong, Coleman, Jennifer, Miskimins, Robin, Miskimins, W Keith
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2003
Materias:	Primary Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC151675/ https://www.ncbi.nlm.nih.gov/pubmed/12633504 http://dx.doi.org/10.1186/1475-2867-3-2

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