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Pesticide-induced immunotoxicity: are Great Lakes residents at risk?

Several organophosphate and organochlorine compounds, including pesticides commonly found in the Great Lakes basin, have the potential to induce immunotoxicity. Because of biomagnification and accumulation in the food chain, Great Lakes residents may inadvertently be exposed to these compounds and t...

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Detalles Bibliográficos
Autor principal: Thomas, P T
Formato: Texto
Lenguaje:English
Publicado: 1995
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1518821/
https://www.ncbi.nlm.nih.gov/pubmed/8635440
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author Thomas, P T
author_facet Thomas, P T
author_sort Thomas, P T
collection PubMed
description Several organophosphate and organochlorine compounds, including pesticides commonly found in the Great Lakes basin, have the potential to induce immunotoxicity. Because of biomagnification and accumulation in the food chain, Great Lakes residents may inadvertently be exposed to these compounds and thus face increased risk of immune dysfunction. In spite of the laboratory animal data and evidence from occupational exposures that suggest immunotoxicity, there is no definitive evidence as yet that environmental exposure to these xenobiotics poses a significant threat to the human immune system that is sufficient to predispose residents of the Great Lakes basin to increased disease. However, uncertainties with regard to exposure levels, predictability of tests, suitability of the animal models, and immune reserve cannot be ruled out when making risk assessment decisions such as this.
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spelling pubmed-15188212006-07-28 Pesticide-induced immunotoxicity: are Great Lakes residents at risk? Thomas, P T Environ Health Perspect Research Article Several organophosphate and organochlorine compounds, including pesticides commonly found in the Great Lakes basin, have the potential to induce immunotoxicity. Because of biomagnification and accumulation in the food chain, Great Lakes residents may inadvertently be exposed to these compounds and thus face increased risk of immune dysfunction. In spite of the laboratory animal data and evidence from occupational exposures that suggest immunotoxicity, there is no definitive evidence as yet that environmental exposure to these xenobiotics poses a significant threat to the human immune system that is sufficient to predispose residents of the Great Lakes basin to increased disease. However, uncertainties with regard to exposure levels, predictability of tests, suitability of the animal models, and immune reserve cannot be ruled out when making risk assessment decisions such as this. 1995-12 /pmc/articles/PMC1518821/ /pubmed/8635440 Text en
spellingShingle Research Article
Thomas, P T
Pesticide-induced immunotoxicity: are Great Lakes residents at risk?
title Pesticide-induced immunotoxicity: are Great Lakes residents at risk?
title_full Pesticide-induced immunotoxicity: are Great Lakes residents at risk?
title_fullStr Pesticide-induced immunotoxicity: are Great Lakes residents at risk?
title_full_unstemmed Pesticide-induced immunotoxicity: are Great Lakes residents at risk?
title_short Pesticide-induced immunotoxicity: are Great Lakes residents at risk?
title_sort pesticide-induced immunotoxicity: are great lakes residents at risk?
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1518821/
https://www.ncbi.nlm.nih.gov/pubmed/8635440
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