Cargando…

Design issues in studies of radon and lung cancer: implications of the joint effect of smoking and radon.

Many case-control studies have been undertaken to assess whether and to what extent residential radon exposure is a risk factor for lung cancer. Nearly all these studies have been conducted in populations including smokers and nonsmokers. In this paper, we show that, depending on the nature of the j...

Descripción completa

Detalles Bibliográficos
Autores principales: Upfal, M, Divine, G, Siemiatycki, J
Formato: Texto
Lenguaje:English
Publicado: 1995
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1519048/
https://www.ncbi.nlm.nih.gov/pubmed/7628427
_version_ 1782128574977802240
author Upfal, M
Divine, G
Siemiatycki, J
author_facet Upfal, M
Divine, G
Siemiatycki, J
author_sort Upfal, M
collection PubMed
description Many case-control studies have been undertaken to assess whether and to what extent residential radon exposure is a risk factor for lung cancer. Nearly all these studies have been conducted in populations including smokers and nonsmokers. In this paper, we show that, depending on the nature of the joint effect of radon and tobacco on lung cancer risk, it may be very difficult to detect a main effect due to radon in mixed smoking and nonsmoking populations. If the joint effect is closer to additive than multiplicative, the most cost-effective way to achieve adequate statistical power may be to conduct a study among never-smokers. Because the underlying joint effect is unknown, and because many studies have been carried out among mixed smoker and nonsmoker populations, it would be desirable to conduct some studies with adequate power among never-smokers only.
format Text
id pubmed-1519048
institution National Center for Biotechnology Information
language English
publishDate 1995
record_format MEDLINE/PubMed
spelling pubmed-15190482006-07-28 Design issues in studies of radon and lung cancer: implications of the joint effect of smoking and radon. Upfal, M Divine, G Siemiatycki, J Environ Health Perspect Research Article Many case-control studies have been undertaken to assess whether and to what extent residential radon exposure is a risk factor for lung cancer. Nearly all these studies have been conducted in populations including smokers and nonsmokers. In this paper, we show that, depending on the nature of the joint effect of radon and tobacco on lung cancer risk, it may be very difficult to detect a main effect due to radon in mixed smoking and nonsmoking populations. If the joint effect is closer to additive than multiplicative, the most cost-effective way to achieve adequate statistical power may be to conduct a study among never-smokers. Because the underlying joint effect is unknown, and because many studies have been carried out among mixed smoker and nonsmoker populations, it would be desirable to conduct some studies with adequate power among never-smokers only. 1995-01 /pmc/articles/PMC1519048/ /pubmed/7628427 Text en
spellingShingle Research Article
Upfal, M
Divine, G
Siemiatycki, J
Design issues in studies of radon and lung cancer: implications of the joint effect of smoking and radon.
title Design issues in studies of radon and lung cancer: implications of the joint effect of smoking and radon.
title_full Design issues in studies of radon and lung cancer: implications of the joint effect of smoking and radon.
title_fullStr Design issues in studies of radon and lung cancer: implications of the joint effect of smoking and radon.
title_full_unstemmed Design issues in studies of radon and lung cancer: implications of the joint effect of smoking and radon.
title_short Design issues in studies of radon and lung cancer: implications of the joint effect of smoking and radon.
title_sort design issues in studies of radon and lung cancer: implications of the joint effect of smoking and radon.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1519048/
https://www.ncbi.nlm.nih.gov/pubmed/7628427
work_keys_str_mv AT upfalm designissuesinstudiesofradonandlungcancerimplicationsofthejointeffectofsmokingandradon
AT divineg designissuesinstudiesofradonandlungcancerimplicationsofthejointeffectofsmokingandradon
AT siemiatyckij designissuesinstudiesofradonandlungcancerimplicationsofthejointeffectofsmokingandradon