Two-stage and Weibull models for carcinogenesis applied to the ED01 discontinued dosing data.

The two-stage clonal expansion model for a single, less-than-lifetime period of dosing is formulated and applied to the liver and bladder tumor data from the ED01 study. The model successfully predicts liver tumor incidence for time points beyond termination of dosing with 2-acetylaminofluorene, but...

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Detalles Bibliográficos
Autores principales: Kodell, R L, Felton, R P
Formato: Texto
Lenguaje:English
Publicado: 1991
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1519382/
https://www.ncbi.nlm.nih.gov/pubmed/1935845
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author Kodell, R L
Felton, R P
author_facet Kodell, R L
Felton, R P
author_sort Kodell, R L
collection PubMed
description The two-stage clonal expansion model for a single, less-than-lifetime period of dosing is formulated and applied to the liver and bladder tumor data from the ED01 study. The model successfully predicts liver tumor incidence for time points beyond termination of dosing with 2-acetylaminofluorene, but it is unsuccessful for bladder tumor incidence. A discontinued dosing version of the Weibull model is proposed and is shown to predict successfully both liver and bladder tumor incidences for time points after termination of dosing.
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spelling pubmed-15193822006-07-26 Two-stage and Weibull models for carcinogenesis applied to the ED01 discontinued dosing data. Kodell, R L Felton, R P Environ Health Perspect Research Article The two-stage clonal expansion model for a single, less-than-lifetime period of dosing is formulated and applied to the liver and bladder tumor data from the ED01 study. The model successfully predicts liver tumor incidence for time points beyond termination of dosing with 2-acetylaminofluorene, but it is unsuccessful for bladder tumor incidence. A discontinued dosing version of the Weibull model is proposed and is shown to predict successfully both liver and bladder tumor incidences for time points after termination of dosing. 1991-05 /pmc/articles/PMC1519382/ /pubmed/1935845 Text en
spellingShingle Research Article
Kodell, R L
Felton, R P
Two-stage and Weibull models for carcinogenesis applied to the ED01 discontinued dosing data.
title Two-stage and Weibull models for carcinogenesis applied to the ED01 discontinued dosing data.
title_full Two-stage and Weibull models for carcinogenesis applied to the ED01 discontinued dosing data.
title_fullStr Two-stage and Weibull models for carcinogenesis applied to the ED01 discontinued dosing data.
title_full_unstemmed Two-stage and Weibull models for carcinogenesis applied to the ED01 discontinued dosing data.
title_short Two-stage and Weibull models for carcinogenesis applied to the ED01 discontinued dosing data.
title_sort two-stage and weibull models for carcinogenesis applied to the ed01 discontinued dosing data.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1519382/
https://www.ncbi.nlm.nih.gov/pubmed/1935845
work_keys_str_mv AT kodellrl twostageandweibullmodelsforcarcinogenesisappliedtotheed01discontinueddosingdata
AT feltonrp twostageandweibullmodelsforcarcinogenesisappliedtotheed01discontinueddosingdata

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