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Cell proliferation and nasal carcinogenesis.
The nasal passages of rodents provide valuable opportunities for research on relationships between cell proliferation and cancer. The nose, which has multiple functions, possesses a diverse range of tissue types, each with its own morphologic, physiologic, and metabolic characteristics and site-spec...
Autores principales: | , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
1993
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1519436/ https://www.ncbi.nlm.nih.gov/pubmed/8013398 |
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author | Monticello, T M Gross, E A Morgan, K T |
author_facet | Monticello, T M Gross, E A Morgan, K T |
author_sort | Monticello, T M |
collection | PubMed |
description | The nasal passages of rodents provide valuable opportunities for research on relationships between cell proliferation and cancer. The nose, which has multiple functions, possesses a diverse range of tissue types, each with its own morphologic, physiologic, and metabolic characteristics and site-specific cell turnover rates. Moreover, for inhaled materials deposited in the nose, complex regional uptake or deposition patterns can result in site-specific responses, including cancer. Presented here are important criteria necessary for undertaking cell proliferation studies in the nasal passages. The current literature concerning nasal toxicity and the toxicant-induced proliferative response are also reviewed. Rodent nasal epithelium provides a fruitful area for research on the role of cell proliferation in carcinogenesis. |
format | Text |
id | pubmed-1519436 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1993 |
record_format | MEDLINE/PubMed |
spelling | pubmed-15194362006-07-26 Cell proliferation and nasal carcinogenesis. Monticello, T M Gross, E A Morgan, K T Environ Health Perspect Research Article The nasal passages of rodents provide valuable opportunities for research on relationships between cell proliferation and cancer. The nose, which has multiple functions, possesses a diverse range of tissue types, each with its own morphologic, physiologic, and metabolic characteristics and site-specific cell turnover rates. Moreover, for inhaled materials deposited in the nose, complex regional uptake or deposition patterns can result in site-specific responses, including cancer. Presented here are important criteria necessary for undertaking cell proliferation studies in the nasal passages. The current literature concerning nasal toxicity and the toxicant-induced proliferative response are also reviewed. Rodent nasal epithelium provides a fruitful area for research on the role of cell proliferation in carcinogenesis. 1993-12 /pmc/articles/PMC1519436/ /pubmed/8013398 Text en |
spellingShingle | Research Article Monticello, T M Gross, E A Morgan, K T Cell proliferation and nasal carcinogenesis. |
title | Cell proliferation and nasal carcinogenesis. |
title_full | Cell proliferation and nasal carcinogenesis. |
title_fullStr | Cell proliferation and nasal carcinogenesis. |
title_full_unstemmed | Cell proliferation and nasal carcinogenesis. |
title_short | Cell proliferation and nasal carcinogenesis. |
title_sort | cell proliferation and nasal carcinogenesis. |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1519436/ https://www.ncbi.nlm.nih.gov/pubmed/8013398 |
work_keys_str_mv | AT monticellotm cellproliferationandnasalcarcinogenesis AT grossea cellproliferationandnasalcarcinogenesis AT morgankt cellproliferationandnasalcarcinogenesis |