Gap junctional intercellular communication and cell proliferation during rat liver carcinogenesis.

During multistage liver carcinogenesis, there is a sequential decrease in gap junctional intercellular communication (GJIC), associated with reduced expression of a major liver gap-junction protein (connexin 32). There are also several lines of evidence indicating that the induction of cell prolifer...

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Detalles Bibliográficos
Autores principales: Yamasaki, H, Krutovskikh, V, Mesnil, M, Columbano, A, Tsuda, H, Ito, N
Formato: Texto
Lenguaje:English
Publicado: 1993
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1519437/
https://www.ncbi.nlm.nih.gov/pubmed/8013409
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author Yamasaki, H
Krutovskikh, V
Mesnil, M
Columbano, A
Tsuda, H
Ito, N
author_facet Yamasaki, H
Krutovskikh, V
Mesnil, M
Columbano, A
Tsuda, H
Ito, N
author_sort Yamasaki, H
collection PubMed
description During multistage liver carcinogenesis, there is a sequential decrease in gap junctional intercellular communication (GJIC), associated with reduced expression of a major liver gap-junction protein (connexin 32). There are also several lines of evidence indicating that the induction of cell proliferation plays an important role during liver carcinogenesis. The relationship between GJIC and cell proliferation and their roles in liver carcinogenesis are not yet known. Results from various experiments suggest that there is a close relationship between the inhibition of GJIC and stimulation of liver cell proliferation. However, our results also suggest that different stimuli may affect cell proliferation and GJIC differentially by different mechanisms.
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spelling pubmed-15194372006-07-26 Gap junctional intercellular communication and cell proliferation during rat liver carcinogenesis. Yamasaki, H Krutovskikh, V Mesnil, M Columbano, A Tsuda, H Ito, N Environ Health Perspect Research Article During multistage liver carcinogenesis, there is a sequential decrease in gap junctional intercellular communication (GJIC), associated with reduced expression of a major liver gap-junction protein (connexin 32). There are also several lines of evidence indicating that the induction of cell proliferation plays an important role during liver carcinogenesis. The relationship between GJIC and cell proliferation and their roles in liver carcinogenesis are not yet known. Results from various experiments suggest that there is a close relationship between the inhibition of GJIC and stimulation of liver cell proliferation. However, our results also suggest that different stimuli may affect cell proliferation and GJIC differentially by different mechanisms. 1993-12 /pmc/articles/PMC1519437/ /pubmed/8013409 Text en
spellingShingle Research Article
Yamasaki, H
Krutovskikh, V
Mesnil, M
Columbano, A
Tsuda, H
Ito, N
Gap junctional intercellular communication and cell proliferation during rat liver carcinogenesis.
title Gap junctional intercellular communication and cell proliferation during rat liver carcinogenesis.
title_full Gap junctional intercellular communication and cell proliferation during rat liver carcinogenesis.
title_fullStr Gap junctional intercellular communication and cell proliferation during rat liver carcinogenesis.
title_full_unstemmed Gap junctional intercellular communication and cell proliferation during rat liver carcinogenesis.
title_short Gap junctional intercellular communication and cell proliferation during rat liver carcinogenesis.
title_sort gap junctional intercellular communication and cell proliferation during rat liver carcinogenesis.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1519437/
https://www.ncbi.nlm.nih.gov/pubmed/8013409
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