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Detection and quantification of ploidy, nuclearity, and DNA synthesis in rat hepatocytes after administration of a peroxisome proliferator.
The peroxisome proliferator methylclofenapate (MCP) induces species-specific liver growth and cancer in rats and mice. The acute hyperplastic effects of MCP were studied in rats given MCP (25 mg/kg by daily gavage) and injected IP (0.5 mL, 50 mM) with bromodeoxyuridine (BrdU) 6 hr before each sampli...
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
1993
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1519464/ https://www.ncbi.nlm.nih.gov/pubmed/8013411 |