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Irreversible pulmonary changes induced in rat lung by dust overload.

The objective of this study was to investigate whether the effects of dust overload are reversible upon cessation of subchronic exposure to test toner. Female rats were exposed 6 hr/day, 5 days/week for 3 months to a test toner at 0, 10, and 40 mg/m3. The retained quantity of test toner in the lungs...

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Detalles Bibliográficos
Autores principales: Bellmann, B, Muhle, H, Creutzenberg, O, Mermelstein, R
Formato: Texto
Lenguaje:English
Publicado: 1992
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1519531/
https://www.ncbi.nlm.nih.gov/pubmed/1396457
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author Bellmann, B
Muhle, H
Creutzenberg, O
Mermelstein, R
author_facet Bellmann, B
Muhle, H
Creutzenberg, O
Mermelstein, R
author_sort Bellmann, B
collection PubMed
description The objective of this study was to investigate whether the effects of dust overload are reversible upon cessation of subchronic exposure to test toner. Female rats were exposed 6 hr/day, 5 days/week for 3 months to a test toner at 0, 10, and 40 mg/m3. The retained quantity of test toner in the lungs at the end of exposure was 0.4 and 3.0 mg for the low and high exposure groups, respectively. Fifteen months later, the corresponding values were 0.12 and 2.65 mg in the lungs. Alveolar clearance of tracer aerosols as well as cytologic and enzymatic parameters in the bronchoalveolar fluid was investigated at the end of exposure and subsequently up to 15 months later. The alveolar clearance of 59Fe2O3, 51Cr-polystyrene, and 85Sr-polystyrene tracer aerosols was slightly retarded at the low and substantially impaired at the high exposure level. At the low exposure level, there was some recovery in the clearance behavior up to 6 months after exposure. In contrast, at the high exposure level there was no indication of a reversal of the impaired clearance. For the beta-glucuronidase activity and the number of polymorphonuclear cells, the pattern of the effects was similar to the effects on the half-time tracer particle clearance. In conclusion, the dust overload at a lung burden of 3 mg test toner in rats was persistent for at least 15 months after termination of exposure.
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spelling pubmed-15195312006-07-26 Irreversible pulmonary changes induced in rat lung by dust overload. Bellmann, B Muhle, H Creutzenberg, O Mermelstein, R Environ Health Perspect Research Article The objective of this study was to investigate whether the effects of dust overload are reversible upon cessation of subchronic exposure to test toner. Female rats were exposed 6 hr/day, 5 days/week for 3 months to a test toner at 0, 10, and 40 mg/m3. The retained quantity of test toner in the lungs at the end of exposure was 0.4 and 3.0 mg for the low and high exposure groups, respectively. Fifteen months later, the corresponding values were 0.12 and 2.65 mg in the lungs. Alveolar clearance of tracer aerosols as well as cytologic and enzymatic parameters in the bronchoalveolar fluid was investigated at the end of exposure and subsequently up to 15 months later. The alveolar clearance of 59Fe2O3, 51Cr-polystyrene, and 85Sr-polystyrene tracer aerosols was slightly retarded at the low and substantially impaired at the high exposure level. At the low exposure level, there was some recovery in the clearance behavior up to 6 months after exposure. In contrast, at the high exposure level there was no indication of a reversal of the impaired clearance. For the beta-glucuronidase activity and the number of polymorphonuclear cells, the pattern of the effects was similar to the effects on the half-time tracer particle clearance. In conclusion, the dust overload at a lung burden of 3 mg test toner in rats was persistent for at least 15 months after termination of exposure. 1992-07 /pmc/articles/PMC1519531/ /pubmed/1396457 Text en
spellingShingle Research Article
Bellmann, B
Muhle, H
Creutzenberg, O
Mermelstein, R
Irreversible pulmonary changes induced in rat lung by dust overload.
title Irreversible pulmonary changes induced in rat lung by dust overload.
title_full Irreversible pulmonary changes induced in rat lung by dust overload.
title_fullStr Irreversible pulmonary changes induced in rat lung by dust overload.
title_full_unstemmed Irreversible pulmonary changes induced in rat lung by dust overload.
title_short Irreversible pulmonary changes induced in rat lung by dust overload.
title_sort irreversible pulmonary changes induced in rat lung by dust overload.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1519531/
https://www.ncbi.nlm.nih.gov/pubmed/1396457
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