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Cage allocation designs for rodent carcinogenicity experiments.

Cage allocation designs for rodent carcinogenicity experiments are discussed and presented with the goal of avoiding dosage group biases related to cage location. Considerations in selecting a cage design are first discussed in general terms. Specific designs are presented for use in experiments inv...

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Detalles Bibliográficos
Autores principales: Herzberg, A M, Lagakos, S W
Formato: Texto
Lenguaje:English
Publicado: 1992
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1519551/
https://www.ncbi.nlm.nih.gov/pubmed/1295494
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author Herzberg, A M
Lagakos, S W
author_facet Herzberg, A M
Lagakos, S W
author_sort Herzberg, A M
collection PubMed
description Cage allocation designs for rodent carcinogenicity experiments are discussed and presented with the goal of avoiding dosage group biases related to cage location. Considerations in selecting a cage design are first discussed in general terms. Specific designs are presented for use in experiments involving three, four, and five dose groups and with one, four, and five rodents per cage. Priorities for balancing treatment groups include horizontal position on shelf and shelf of rack, nearest neighbor balance, and male-female balance. It is proposed that these balance criteria be considered together with practical issues, such as the ability to accurately conform to a design and to determine a sensible and efficient design for each experiment.
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spelling pubmed-15195512006-07-26 Cage allocation designs for rodent carcinogenicity experiments. Herzberg, A M Lagakos, S W Environ Health Perspect Research Article Cage allocation designs for rodent carcinogenicity experiments are discussed and presented with the goal of avoiding dosage group biases related to cage location. Considerations in selecting a cage design are first discussed in general terms. Specific designs are presented for use in experiments involving three, four, and five dose groups and with one, four, and five rodents per cage. Priorities for balancing treatment groups include horizontal position on shelf and shelf of rack, nearest neighbor balance, and male-female balance. It is proposed that these balance criteria be considered together with practical issues, such as the ability to accurately conform to a design and to determine a sensible and efficient design for each experiment. 1992-07 /pmc/articles/PMC1519551/ /pubmed/1295494 Text en
spellingShingle Research Article
Herzberg, A M
Lagakos, S W
Cage allocation designs for rodent carcinogenicity experiments.
title Cage allocation designs for rodent carcinogenicity experiments.
title_full Cage allocation designs for rodent carcinogenicity experiments.
title_fullStr Cage allocation designs for rodent carcinogenicity experiments.
title_full_unstemmed Cage allocation designs for rodent carcinogenicity experiments.
title_short Cage allocation designs for rodent carcinogenicity experiments.
title_sort cage allocation designs for rodent carcinogenicity experiments.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1519551/
https://www.ncbi.nlm.nih.gov/pubmed/1295494
work_keys_str_mv AT herzbergam cageallocationdesignsforrodentcarcinogenicityexperiments
AT lagakossw cageallocationdesignsforrodentcarcinogenicityexperiments