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Determinants of serum zinc in a random population sample of four Belgian towns with different degrees of environmental exposure to cadmium

This report investigated the distribution of serum zinc and the factors determining serum zinc concentration in a large random population sample. The 1977 participants (959 men and 1018 women), 20–80 years old, constituted a stratified random sample of the population of four Belgian districts, repre...

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Autores principales: Thijs, Lutgarde, Staessen, Jan, Amery, Antoon, Bruaux, Pierre, Buchet, Jean-Pierre, Claeys, FranÇoise, De Plaen, Pierre, Ducoffre, Geneviève, Lauwerys, Robert, Lijnen, Paul, Nick, Laurence, Remy, Annie Saint, Roels, Harry, Rondia, Désiré, Sartor, Francis
Formato: Texto
Lenguaje:English
Publicado: 1992
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1519594/
https://www.ncbi.nlm.nih.gov/pubmed/1486857
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author Thijs, Lutgarde
Staessen, Jan
Amery, Antoon
Bruaux, Pierre
Buchet, Jean-Pierre
Claeys, FranÇoise
De Plaen, Pierre
Ducoffre, Geneviève
Lauwerys, Robert
Lijnen, Paul
Nick, Laurence
Remy, Annie Saint
Roels, Harry
Rondia, Désiré
Sartor, Francis
author_facet Thijs, Lutgarde
Staessen, Jan
Amery, Antoon
Bruaux, Pierre
Buchet, Jean-Pierre
Claeys, FranÇoise
De Plaen, Pierre
Ducoffre, Geneviève
Lauwerys, Robert
Lijnen, Paul
Nick, Laurence
Remy, Annie Saint
Roels, Harry
Rondia, Désiré
Sartor, Francis
author_sort Thijs, Lutgarde
collection PubMed
description This report investigated the distribution of serum zinc and the factors determining serum zinc concentration in a large random population sample. The 1977 participants (959 men and 1018 women), 20–80 years old, constituted a stratified random sample of the population of four Belgian districts, representing two areas with low and two with high environmental exposure to cadmium. For each exposure level, a rural and an urban area were selected. The serum concentration of zinc, frequently used as an index for zinc status in human subjects, was higher in men (13.1 μmole/L, range 6.5–23.0 μmole/L) than in women (12.6 μmole/L, range 6.3–23.2 μmole/L). In men, 20% of the variance of serum zinc was explained by age (linear and squared term, R = 0.29), diurnal variation (r = 0.29), and total cholesterol (r = 0.16). After adjustment for these covariates, a negative relationship was observed between serum zinc and both blood (r = −0.10) and urinary cadmium (r = −0.14). In women, 11% of the variance could be explained by age (linear and squared term, R = 0.15), diurnal variation in serum zinc (r = 0.27), creatinine clearance (r = −0.11), log γ-glutamyltranspeptidase (r = 0.08), cholesterol (r = 0.07), contraceptive pill intake (r = −0.07), and log serum ferritin (r = 0.06). Before and after adjustment for significant covariates, serum zinc was, on average, lowest in the two districts where the body burden of cadmium, as assessed by urinary cadmium excretion, was highest. These results were not altered when subjects exposed to heavy metals at work were excluded from analysis.
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spelling pubmed-15195942006-07-26 Determinants of serum zinc in a random population sample of four Belgian towns with different degrees of environmental exposure to cadmium Thijs, Lutgarde Staessen, Jan Amery, Antoon Bruaux, Pierre Buchet, Jean-Pierre Claeys, FranÇoise De Plaen, Pierre Ducoffre, Geneviève Lauwerys, Robert Lijnen, Paul Nick, Laurence Remy, Annie Saint Roels, Harry Rondia, Désiré Sartor, Francis Environ Health Perspect Contributed Articles This report investigated the distribution of serum zinc and the factors determining serum zinc concentration in a large random population sample. The 1977 participants (959 men and 1018 women), 20–80 years old, constituted a stratified random sample of the population of four Belgian districts, representing two areas with low and two with high environmental exposure to cadmium. For each exposure level, a rural and an urban area were selected. The serum concentration of zinc, frequently used as an index for zinc status in human subjects, was higher in men (13.1 μmole/L, range 6.5–23.0 μmole/L) than in women (12.6 μmole/L, range 6.3–23.2 μmole/L). In men, 20% of the variance of serum zinc was explained by age (linear and squared term, R = 0.29), diurnal variation (r = 0.29), and total cholesterol (r = 0.16). After adjustment for these covariates, a negative relationship was observed between serum zinc and both blood (r = −0.10) and urinary cadmium (r = −0.14). In women, 11% of the variance could be explained by age (linear and squared term, R = 0.15), diurnal variation in serum zinc (r = 0.27), creatinine clearance (r = −0.11), log γ-glutamyltranspeptidase (r = 0.08), cholesterol (r = 0.07), contraceptive pill intake (r = −0.07), and log serum ferritin (r = 0.06). Before and after adjustment for significant covariates, serum zinc was, on average, lowest in the two districts where the body burden of cadmium, as assessed by urinary cadmium excretion, was highest. These results were not altered when subjects exposed to heavy metals at work were excluded from analysis. 1992-11 /pmc/articles/PMC1519594/ /pubmed/1486857 Text en
spellingShingle Contributed Articles
Thijs, Lutgarde
Staessen, Jan
Amery, Antoon
Bruaux, Pierre
Buchet, Jean-Pierre
Claeys, FranÇoise
De Plaen, Pierre
Ducoffre, Geneviève
Lauwerys, Robert
Lijnen, Paul
Nick, Laurence
Remy, Annie Saint
Roels, Harry
Rondia, Désiré
Sartor, Francis
Determinants of serum zinc in a random population sample of four Belgian towns with different degrees of environmental exposure to cadmium
title Determinants of serum zinc in a random population sample of four Belgian towns with different degrees of environmental exposure to cadmium
title_full Determinants of serum zinc in a random population sample of four Belgian towns with different degrees of environmental exposure to cadmium
title_fullStr Determinants of serum zinc in a random population sample of four Belgian towns with different degrees of environmental exposure to cadmium
title_full_unstemmed Determinants of serum zinc in a random population sample of four Belgian towns with different degrees of environmental exposure to cadmium
title_short Determinants of serum zinc in a random population sample of four Belgian towns with different degrees of environmental exposure to cadmium
title_sort determinants of serum zinc in a random population sample of four belgian towns with different degrees of environmental exposure to cadmium
topic Contributed Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1519594/
https://www.ncbi.nlm.nih.gov/pubmed/1486857
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