Elucidation of catalytic specificities of human cytochrome P450 and glutathione S-transferase enzymes and relevance to molecular epidemiology.

A number of different approaches have been used to determine the catalytic selectivity of individual human enzymes toward procarcinogens. Studies with cytochrome P450 (P450) enzymes and glutathione S-transferases are summarized here, and recent work with pyrrolizidine alkaloids, aflatoxins, 4,4'...

Descripción completa

Detalles Bibliográficos
Autores principales: Guengerich, F P, Shimada, T, Raney, K D, Yun, C H, Meyer, D J, Ketterer, B, Harris, T M, Groopman, J D, Kadlubar, F F
Formato: Texto
Lenguaje:English
Publicado: 1992
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1519604/
https://www.ncbi.nlm.nih.gov/pubmed/1486866
_version_ 1782128688937041920
author Guengerich, F P
Shimada, T
Raney, K D
Yun, C H
Meyer, D J
Ketterer, B
Harris, T M
Groopman, J D
Kadlubar, F F
author_facet Guengerich, F P
Shimada, T
Raney, K D
Yun, C H
Meyer, D J
Ketterer, B
Harris, T M
Groopman, J D
Kadlubar, F F
author_sort Guengerich, F P
collection PubMed
description A number of different approaches have been used to determine the catalytic selectivity of individual human enzymes toward procarcinogens. Studies with cytochrome P450 (P450) enzymes and glutathione S-transferases are summarized here, and recent work with pyrrolizidine alkaloids, aflatoxins, 4,4'-methylenebis(2-chloroaniline), and ethyl carbamate is discussed. In some cases a single enzyme can catalyze both activation and detoxication reactions of a chemical. The purification and characterization of human lung P4501A1 and the development of a noninvasive assay for human P4502E1 are also described.
format Text
id pubmed-1519604
institution National Center for Biotechnology Information
language English
publishDate 1992
record_format MEDLINE/PubMed
spelling pubmed-15196042006-07-26 Elucidation of catalytic specificities of human cytochrome P450 and glutathione S-transferase enzymes and relevance to molecular epidemiology. Guengerich, F P Shimada, T Raney, K D Yun, C H Meyer, D J Ketterer, B Harris, T M Groopman, J D Kadlubar, F F Environ Health Perspect Research Article A number of different approaches have been used to determine the catalytic selectivity of individual human enzymes toward procarcinogens. Studies with cytochrome P450 (P450) enzymes and glutathione S-transferases are summarized here, and recent work with pyrrolizidine alkaloids, aflatoxins, 4,4'-methylenebis(2-chloroaniline), and ethyl carbamate is discussed. In some cases a single enzyme can catalyze both activation and detoxication reactions of a chemical. The purification and characterization of human lung P4501A1 and the development of a noninvasive assay for human P4502E1 are also described. 1992-11 /pmc/articles/PMC1519604/ /pubmed/1486866 Text en
spellingShingle Research Article
Guengerich, F P
Shimada, T
Raney, K D
Yun, C H
Meyer, D J
Ketterer, B
Harris, T M
Groopman, J D
Kadlubar, F F
Elucidation of catalytic specificities of human cytochrome P450 and glutathione S-transferase enzymes and relevance to molecular epidemiology.
title Elucidation of catalytic specificities of human cytochrome P450 and glutathione S-transferase enzymes and relevance to molecular epidemiology.
title_full Elucidation of catalytic specificities of human cytochrome P450 and glutathione S-transferase enzymes and relevance to molecular epidemiology.
title_fullStr Elucidation of catalytic specificities of human cytochrome P450 and glutathione S-transferase enzymes and relevance to molecular epidemiology.
title_full_unstemmed Elucidation of catalytic specificities of human cytochrome P450 and glutathione S-transferase enzymes and relevance to molecular epidemiology.
title_short Elucidation of catalytic specificities of human cytochrome P450 and glutathione S-transferase enzymes and relevance to molecular epidemiology.
title_sort elucidation of catalytic specificities of human cytochrome p450 and glutathione s-transferase enzymes and relevance to molecular epidemiology.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1519604/
https://www.ncbi.nlm.nih.gov/pubmed/1486866
work_keys_str_mv AT guengerichfp elucidationofcatalyticspecificitiesofhumancytochromep450andglutathionestransferaseenzymesandrelevancetomolecularepidemiology
AT shimadat elucidationofcatalyticspecificitiesofhumancytochromep450andglutathionestransferaseenzymesandrelevancetomolecularepidemiology
AT raneykd elucidationofcatalyticspecificitiesofhumancytochromep450andglutathionestransferaseenzymesandrelevancetomolecularepidemiology
AT yunch elucidationofcatalyticspecificitiesofhumancytochromep450andglutathionestransferaseenzymesandrelevancetomolecularepidemiology
AT meyerdj elucidationofcatalyticspecificitiesofhumancytochromep450andglutathionestransferaseenzymesandrelevancetomolecularepidemiology
AT kettererb elucidationofcatalyticspecificitiesofhumancytochromep450andglutathionestransferaseenzymesandrelevancetomolecularepidemiology
AT harristm elucidationofcatalyticspecificitiesofhumancytochromep450andglutathionestransferaseenzymesandrelevancetomolecularepidemiology
AT groopmanjd elucidationofcatalyticspecificitiesofhumancytochromep450andglutathionestransferaseenzymesandrelevancetomolecularepidemiology
AT kadlubarff elucidationofcatalyticspecificitiesofhumancytochromep450andglutathionestransferaseenzymesandrelevancetomolecularepidemiology

Ejemplares similares