Allele diversity of the H-ras-1 variable number of tandem repeats in Norwegian lung cancer patients.

We have examined restriction fragment length polymorphisms of the H-ras-1 gene in germ-line DNA from 214 lung cancer patients and 309 unaffected controls. When DNA samples were digested with MspI/HpaII, Southern blot analysis revealed at least 22 different alleles, grouped according to their frequen...

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Detalles Bibliográficos
Autores principales: Ryberg, D, Tefre, T, Skaug, V, Stangeland, L, Ovrebø, S, Naalsund, A, Børresen, A L, Haugen, A
Formato: Texto
Lenguaje:English
Publicado: 1992
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1519637/
https://www.ncbi.nlm.nih.gov/pubmed/1362538
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author Ryberg, D
Tefre, T
Skaug, V
Stangeland, L
Ovrebø, S
Naalsund, A
Børresen, A L
Haugen, A
author_facet Ryberg, D
Tefre, T
Skaug, V
Stangeland, L
Ovrebø, S
Naalsund, A
Børresen, A L
Haugen, A
author_sort Ryberg, D
collection PubMed
description We have examined restriction fragment length polymorphisms of the H-ras-1 gene in germ-line DNA from 214 lung cancer patients and 309 unaffected controls. When DNA samples were digested with MspI/HpaII, Southern blot analysis revealed at least 22 different alleles, grouped according to their frequencies as common, intermediate, and rare. The frequency of rare alleles in lung cancer patients (16/428) is significantly different (p = 0.002) from that in the control group (5/618). Individuals with rare alleles were found to be at 4.7-fold greater risk of lung cancer than those with no rare alleles.
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spelling pubmed-15196372006-07-26 Allele diversity of the H-ras-1 variable number of tandem repeats in Norwegian lung cancer patients. Ryberg, D Tefre, T Skaug, V Stangeland, L Ovrebø, S Naalsund, A Børresen, A L Haugen, A Environ Health Perspect Research Article We have examined restriction fragment length polymorphisms of the H-ras-1 gene in germ-line DNA from 214 lung cancer patients and 309 unaffected controls. When DNA samples were digested with MspI/HpaII, Southern blot analysis revealed at least 22 different alleles, grouped according to their frequencies as common, intermediate, and rare. The frequency of rare alleles in lung cancer patients (16/428) is significantly different (p = 0.002) from that in the control group (5/618). Individuals with rare alleles were found to be at 4.7-fold greater risk of lung cancer than those with no rare alleles. 1992-11 /pmc/articles/PMC1519637/ /pubmed/1362538 Text en
spellingShingle Research Article
Ryberg, D
Tefre, T
Skaug, V
Stangeland, L
Ovrebø, S
Naalsund, A
Børresen, A L
Haugen, A
Allele diversity of the H-ras-1 variable number of tandem repeats in Norwegian lung cancer patients.
title Allele diversity of the H-ras-1 variable number of tandem repeats in Norwegian lung cancer patients.
title_full Allele diversity of the H-ras-1 variable number of tandem repeats in Norwegian lung cancer patients.
title_fullStr Allele diversity of the H-ras-1 variable number of tandem repeats in Norwegian lung cancer patients.
title_full_unstemmed Allele diversity of the H-ras-1 variable number of tandem repeats in Norwegian lung cancer patients.
title_short Allele diversity of the H-ras-1 variable number of tandem repeats in Norwegian lung cancer patients.
title_sort allele diversity of the h-ras-1 variable number of tandem repeats in norwegian lung cancer patients.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1519637/
https://www.ncbi.nlm.nih.gov/pubmed/1362538
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