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Physiologically based toxicokinetic modeling of 1,3-butadiene lung metabolism in mice becomes more important at low doses.

This paper describes a physiologically based toxicokinetic model for 1,3-butadiene uptake, distribution, and metabolic clearance in mice. Model parameters for metabolic activity were estimated from the correspondence between computer simulation studies and experimental results as published in the li...

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Detalles Bibliográficos
Autores principales: Evelo, C T, Oostendorp, J G, ten Berge, W F, Borm, P J
Formato: Texto
Lenguaje:English
Publicado: 1993
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1519919/
https://www.ncbi.nlm.nih.gov/pubmed/8137778

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