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Enhancement of chromosomal damage by arsenic: implications for mechanism.

Arsenic is a naturally occurring metalloid that has been associated with increased incidence of human cancer in certain highly exposed populations. Arsenic is released to the environment by natural means such as solubilization from geologic formations into water supplies. It is also released to occu...

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Detalles Bibliográficos
Autores principales: Yager, J W, Wiencke, J K
Formato: Texto
Lenguaje:English
Publicado: 1993
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1521136/
https://www.ncbi.nlm.nih.gov/pubmed/8143651
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author Yager, J W
Wiencke, J K
author_facet Yager, J W
Wiencke, J K
author_sort Yager, J W
collection PubMed
description Arsenic is a naturally occurring metalloid that has been associated with increased incidence of human cancer in certain highly exposed populations. Arsenic is released to the environment by natural means such as solubilization from geologic formations into water supplies. It is also released to occupational and community environments by such activities as nonferrous ore smelting and combustion of fuels containing arsenic. Several lines of evidence indicate that arsenic acts indirectly with other agents to ultimately enhance specific genotoxic effects that may lead to carcinogenesis. Work described here indicates that arsenite specifically potentiates chromosomal aberrations induced by a DNA crosslinking agent, 1,3-butadiene diepoxide, but does not effect the induction of sister chromatid exchanges under the same treatment conditions. It is proposed that the specific co-clastogenic effects of arsenite seen here may be mediated by its interference with DNA repair activities. Further understanding of the mechanism by which arsenic interacts with other environmental agents will result in more accurate estimates of risk from exposure to arsenic.
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spelling pubmed-15211362006-07-26 Enhancement of chromosomal damage by arsenic: implications for mechanism. Yager, J W Wiencke, J K Environ Health Perspect Research Article Arsenic is a naturally occurring metalloid that has been associated with increased incidence of human cancer in certain highly exposed populations. Arsenic is released to the environment by natural means such as solubilization from geologic formations into water supplies. It is also released to occupational and community environments by such activities as nonferrous ore smelting and combustion of fuels containing arsenic. Several lines of evidence indicate that arsenic acts indirectly with other agents to ultimately enhance specific genotoxic effects that may lead to carcinogenesis. Work described here indicates that arsenite specifically potentiates chromosomal aberrations induced by a DNA crosslinking agent, 1,3-butadiene diepoxide, but does not effect the induction of sister chromatid exchanges under the same treatment conditions. It is proposed that the specific co-clastogenic effects of arsenite seen here may be mediated by its interference with DNA repair activities. Further understanding of the mechanism by which arsenic interacts with other environmental agents will result in more accurate estimates of risk from exposure to arsenic. 1993-10 /pmc/articles/PMC1521136/ /pubmed/8143651 Text en
spellingShingle Research Article
Yager, J W
Wiencke, J K
Enhancement of chromosomal damage by arsenic: implications for mechanism.
title Enhancement of chromosomal damage by arsenic: implications for mechanism.
title_full Enhancement of chromosomal damage by arsenic: implications for mechanism.
title_fullStr Enhancement of chromosomal damage by arsenic: implications for mechanism.
title_full_unstemmed Enhancement of chromosomal damage by arsenic: implications for mechanism.
title_short Enhancement of chromosomal damage by arsenic: implications for mechanism.
title_sort enhancement of chromosomal damage by arsenic: implications for mechanism.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1521136/
https://www.ncbi.nlm.nih.gov/pubmed/8143651
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