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The hypoactive corpora cavernosa with degenerative erectile dysfunction: a new syndrome

BACKGROUND: In a group of 22 patients with erectile dysfunction, vasculogenic, neurogenic, endocrinologic or psychogenic investigations failed to find a cause for their erectile dysfunction. The electro-cavernosograms of these patients recorded a diminished activity. We investigated the hypothesis t...

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Autores principales: Shafik, Ahmed, Ahmed, Ismail, El Sibai, Olfat, Shafik, Ali A
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1523357/
https://www.ncbi.nlm.nih.gov/pubmed/16723018
http://dx.doi.org/10.1186/1471-2490-6-13
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author Shafik, Ahmed
Ahmed, Ismail
El Sibai, Olfat
Shafik, Ali A
author_facet Shafik, Ahmed
Ahmed, Ismail
El Sibai, Olfat
Shafik, Ali A
author_sort Shafik, Ahmed
collection PubMed
description BACKGROUND: In a group of 22 patients with erectile dysfunction, vasculogenic, neurogenic, endocrinologic or psychogenic investigations failed to find a cause for their erectile dysfunction. The electro-cavernosograms of these patients recorded a diminished activity. We investigated the hypothesis that diminished corpus cavernosum electromyography activity was the cause of erectile dysfunction in these patients. METHODS: The study comprised the above mentioned 22 patients (study group, 43.8 ± 5.9 SD years) and 15 healthy volunteers (control group, 41.8 ± 5.1 SD years). The electro-cavernosograms were recorded in the flaccid, erectile and detumescent phases by 2 electrodes inserted into the corpus cavernosum. RESULTS: The electro-cavernosogram of the healthy volunteers registered in the flaccid phase regular slow waves and random action potentials. The wave variables declined significantly in the erectile phase (p < 0.01). In the study group, the slow wave variables in the flaccid phase exhibited a significant decrease (p < 0.05) compared to the healthy volunteers, and the rhythm was irregular. Erection did not occur with sildenafil administration or intracavernosal papaverine injection, and penile implant was performed. Biopsy examination showed degenerated muscle fibers, and fragmented collagen and elastic fibers with areas of fibrosis. CONCLUSION: A novel concept of the cause of erectile dysfunction was presented. Corpora cavernosa showed degenerative changes on histopathologic examination and exhibited diminished electromyography activity. They did not respond to sildenafil administration or intracavernosal papaverine injection. Penile implants were the only treatment. The condition is given the name 'hypoactive corpus cavernosum'. The cause of corpus cavernosum degenerative changes needs further study.
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spelling pubmed-15233572006-07-28 The hypoactive corpora cavernosa with degenerative erectile dysfunction: a new syndrome Shafik, Ahmed Ahmed, Ismail El Sibai, Olfat Shafik, Ali A BMC Urol Research Article BACKGROUND: In a group of 22 patients with erectile dysfunction, vasculogenic, neurogenic, endocrinologic or psychogenic investigations failed to find a cause for their erectile dysfunction. The electro-cavernosograms of these patients recorded a diminished activity. We investigated the hypothesis that diminished corpus cavernosum electromyography activity was the cause of erectile dysfunction in these patients. METHODS: The study comprised the above mentioned 22 patients (study group, 43.8 ± 5.9 SD years) and 15 healthy volunteers (control group, 41.8 ± 5.1 SD years). The electro-cavernosograms were recorded in the flaccid, erectile and detumescent phases by 2 electrodes inserted into the corpus cavernosum. RESULTS: The electro-cavernosogram of the healthy volunteers registered in the flaccid phase regular slow waves and random action potentials. The wave variables declined significantly in the erectile phase (p < 0.01). In the study group, the slow wave variables in the flaccid phase exhibited a significant decrease (p < 0.05) compared to the healthy volunteers, and the rhythm was irregular. Erection did not occur with sildenafil administration or intracavernosal papaverine injection, and penile implant was performed. Biopsy examination showed degenerated muscle fibers, and fragmented collagen and elastic fibers with areas of fibrosis. CONCLUSION: A novel concept of the cause of erectile dysfunction was presented. Corpora cavernosa showed degenerative changes on histopathologic examination and exhibited diminished electromyography activity. They did not respond to sildenafil administration or intracavernosal papaverine injection. Penile implants were the only treatment. The condition is given the name 'hypoactive corpus cavernosum'. The cause of corpus cavernosum degenerative changes needs further study. BioMed Central 2006-05-24 /pmc/articles/PMC1523357/ /pubmed/16723018 http://dx.doi.org/10.1186/1471-2490-6-13 Text en Copyright © 2006 Shafik et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Shafik, Ahmed
Ahmed, Ismail
El Sibai, Olfat
Shafik, Ali A
The hypoactive corpora cavernosa with degenerative erectile dysfunction: a new syndrome
title The hypoactive corpora cavernosa with degenerative erectile dysfunction: a new syndrome
title_full The hypoactive corpora cavernosa with degenerative erectile dysfunction: a new syndrome
title_fullStr The hypoactive corpora cavernosa with degenerative erectile dysfunction: a new syndrome
title_full_unstemmed The hypoactive corpora cavernosa with degenerative erectile dysfunction: a new syndrome
title_short The hypoactive corpora cavernosa with degenerative erectile dysfunction: a new syndrome
title_sort hypoactive corpora cavernosa with degenerative erectile dysfunction: a new syndrome
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1523357/
https://www.ncbi.nlm.nih.gov/pubmed/16723018
http://dx.doi.org/10.1186/1471-2490-6-13
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