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Miniature bioreactors: current practices and future opportunities

This review focuses on the emerging field of miniature bioreactors (MBRs), and examines the way in which they are used to speed up many areas of bioprocessing. MBRs aim to achieve this acceleration as a result of their inherent high-throughput capability, which results from their ability to perform...

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Detalles Bibliográficos
Autores principales: Betts, Jonathan I, Baganz, Frank
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1523360/
https://www.ncbi.nlm.nih.gov/pubmed/16725043
http://dx.doi.org/10.1186/1475-2859-5-21
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author Betts, Jonathan I
Baganz, Frank
author_facet Betts, Jonathan I
Baganz, Frank
author_sort Betts, Jonathan I
collection PubMed
description This review focuses on the emerging field of miniature bioreactors (MBRs), and examines the way in which they are used to speed up many areas of bioprocessing. MBRs aim to achieve this acceleration as a result of their inherent high-throughput capability, which results from their ability to perform many cell cultivations in parallel. There are several applications for MBRs, ranging from media development and strain improvement to process optimisation. The potential of MBRs for use in these applications will be explained in detail in this review. MBRs are currently based on several existing bioreactor platforms such as shaken devices, stirred-tank reactors and bubble columns. This review will present the advantages and disadvantages of each design together with an appraisal of prototype and commercialised devices developed for parallel operation. Finally we will discuss how MBRs can be used in conjunction with automated robotic systems and other miniature process units to deliver a fully-integrated, high-throughput (HT) solution for cell cultivation process development.
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spelling pubmed-15233602006-07-28 Miniature bioreactors: current practices and future opportunities Betts, Jonathan I Baganz, Frank Microb Cell Fact Review This review focuses on the emerging field of miniature bioreactors (MBRs), and examines the way in which they are used to speed up many areas of bioprocessing. MBRs aim to achieve this acceleration as a result of their inherent high-throughput capability, which results from their ability to perform many cell cultivations in parallel. There are several applications for MBRs, ranging from media development and strain improvement to process optimisation. The potential of MBRs for use in these applications will be explained in detail in this review. MBRs are currently based on several existing bioreactor platforms such as shaken devices, stirred-tank reactors and bubble columns. This review will present the advantages and disadvantages of each design together with an appraisal of prototype and commercialised devices developed for parallel operation. Finally we will discuss how MBRs can be used in conjunction with automated robotic systems and other miniature process units to deliver a fully-integrated, high-throughput (HT) solution for cell cultivation process development. BioMed Central 2006-05-25 /pmc/articles/PMC1523360/ /pubmed/16725043 http://dx.doi.org/10.1186/1475-2859-5-21 Text en Copyright © 2006 Betts and Baganz; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Betts, Jonathan I
Baganz, Frank
Miniature bioreactors: current practices and future opportunities
title Miniature bioreactors: current practices and future opportunities
title_full Miniature bioreactors: current practices and future opportunities
title_fullStr Miniature bioreactors: current practices and future opportunities
title_full_unstemmed Miniature bioreactors: current practices and future opportunities
title_short Miniature bioreactors: current practices and future opportunities
title_sort miniature bioreactors: current practices and future opportunities
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1523360/
https://www.ncbi.nlm.nih.gov/pubmed/16725043
http://dx.doi.org/10.1186/1475-2859-5-21
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