No association between chronic musculoskeletal complaints and Val158Met polymorphism in the Catechol-O-methyltransferase gene. The HUNT study

BACKGROUND: The Catechol-O-methyltransferase (COMT) gene contains a functional polymorphism, Val158Met, that has been found to influence human pain perception. In one study fibromyalgia was less likely among those with Val/Val genotype. METHODS: In the 1995–97 Nord-Trøndelag Health Study (HUNT), the...

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Autores principales: Hagen, Knut, Pettersen, Elin, Stovner, Lars Jacob, Skorpen, Frank, Zwart, John-Anker
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1524765/
https://www.ncbi.nlm.nih.gov/pubmed/16674809
http://dx.doi.org/10.1186/1471-2474-7-40
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author Hagen, Knut
Pettersen, Elin
Stovner, Lars Jacob
Skorpen, Frank
Zwart, John-Anker
author_facet Hagen, Knut
Pettersen, Elin
Stovner, Lars Jacob
Skorpen, Frank
Zwart, John-Anker
author_sort Hagen, Knut
collection PubMed
description BACKGROUND: The Catechol-O-methyltransferase (COMT) gene contains a functional polymorphism, Val158Met, that has been found to influence human pain perception. In one study fibromyalgia was less likely among those with Val/Val genotype. METHODS: In the 1995–97 Nord-Trøndelag Health Study (HUNT), the association between Val/Met polymorphism at the COMT gene and chronic musculoskeletal complaints (MSCs) was evaluated in a random sample of 3017 individuals. RESULTS: The distribution of the COMT Val158Met genotypes and alleles were similar between controls and the twelve different chronic MSCs groups. Even when the Met/Met and Val/Met genotypes were pooled, the distribution of the Val/Val genotype and other genotypes were similar between controls and the chronic MSCs groups. CONCLUSION: In this population-based study, no significant association was found between Val/Met polymorphism at the COMT gene and chronic MSCs.
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spelling pubmed-15247652006-07-29 No association between chronic musculoskeletal complaints and Val158Met polymorphism in the Catechol-O-methyltransferase gene. The HUNT study Hagen, Knut Pettersen, Elin Stovner, Lars Jacob Skorpen, Frank Zwart, John-Anker BMC Musculoskelet Disord Research Article BACKGROUND: The Catechol-O-methyltransferase (COMT) gene contains a functional polymorphism, Val158Met, that has been found to influence human pain perception. In one study fibromyalgia was less likely among those with Val/Val genotype. METHODS: In the 1995–97 Nord-Trøndelag Health Study (HUNT), the association between Val/Met polymorphism at the COMT gene and chronic musculoskeletal complaints (MSCs) was evaluated in a random sample of 3017 individuals. RESULTS: The distribution of the COMT Val158Met genotypes and alleles were similar between controls and the twelve different chronic MSCs groups. Even when the Met/Met and Val/Met genotypes were pooled, the distribution of the Val/Val genotype and other genotypes were similar between controls and the chronic MSCs groups. CONCLUSION: In this population-based study, no significant association was found between Val/Met polymorphism at the COMT gene and chronic MSCs. BioMed Central 2006-05-04 /pmc/articles/PMC1524765/ /pubmed/16674809 http://dx.doi.org/10.1186/1471-2474-7-40 Text en Copyright © 2006 Hagen et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Hagen, Knut
Pettersen, Elin
Stovner, Lars Jacob
Skorpen, Frank
Zwart, John-Anker
No association between chronic musculoskeletal complaints and Val158Met polymorphism in the Catechol-O-methyltransferase gene. The HUNT study
title No association between chronic musculoskeletal complaints and Val158Met polymorphism in the Catechol-O-methyltransferase gene. The HUNT study
title_full No association between chronic musculoskeletal complaints and Val158Met polymorphism in the Catechol-O-methyltransferase gene. The HUNT study
title_fullStr No association between chronic musculoskeletal complaints and Val158Met polymorphism in the Catechol-O-methyltransferase gene. The HUNT study
title_full_unstemmed No association between chronic musculoskeletal complaints and Val158Met polymorphism in the Catechol-O-methyltransferase gene. The HUNT study
title_short No association between chronic musculoskeletal complaints and Val158Met polymorphism in the Catechol-O-methyltransferase gene. The HUNT study
title_sort no association between chronic musculoskeletal complaints and val158met polymorphism in the catechol-o-methyltransferase gene. the hunt study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1524765/
https://www.ncbi.nlm.nih.gov/pubmed/16674809
http://dx.doi.org/10.1186/1471-2474-7-40
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