Regulation of ovulation rate in mammals: contribution of sheep genetic models

Ovarian folliculogenesis in mammals from the constitution of primordial follicles up to ovulation is a reasonably well understood mechanism. Nevertheless, underlying mechanisms that determine the number of ovulating follicles were enigmatic until the identification of the fecundity genes affecting o...

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Autores principales: Fabre, Stéphane, Pierre, Alice, Mulsant, Philippe, Bodin, Loys, Di Pasquale, Elisa, Persani, Luca, Monget, Philippe, Monniaux, Danielle
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1524776/
https://www.ncbi.nlm.nih.gov/pubmed/16611365
http://dx.doi.org/10.1186/1477-7827-4-20
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author Fabre, Stéphane
Pierre, Alice
Mulsant, Philippe
Bodin, Loys
Di Pasquale, Elisa
Persani, Luca
Monget, Philippe
Monniaux, Danielle
author_facet Fabre, Stéphane
Pierre, Alice
Mulsant, Philippe
Bodin, Loys
Di Pasquale, Elisa
Persani, Luca
Monget, Philippe
Monniaux, Danielle
author_sort Fabre, Stéphane
collection PubMed
description Ovarian folliculogenesis in mammals from the constitution of primordial follicles up to ovulation is a reasonably well understood mechanism. Nevertheless, underlying mechanisms that determine the number of ovulating follicles were enigmatic until the identification of the fecundity genes affecting ovulation rate in sheep, bone morphogenetic protein-15 (BMP-15), growth and differentiation factor-9 (GDF-9) and BMP receptor-1B (BMPR-1B). In this review, we focus on the use of these sheep genetic models for understanding the role of the BMP system as an intra-ovarian regulator of follicular growth and maturation, and finally, ovulation rate.
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spelling pubmed-15247762006-07-29 Regulation of ovulation rate in mammals: contribution of sheep genetic models Fabre, Stéphane Pierre, Alice Mulsant, Philippe Bodin, Loys Di Pasquale, Elisa Persani, Luca Monget, Philippe Monniaux, Danielle Reprod Biol Endocrinol Review Ovarian folliculogenesis in mammals from the constitution of primordial follicles up to ovulation is a reasonably well understood mechanism. Nevertheless, underlying mechanisms that determine the number of ovulating follicles were enigmatic until the identification of the fecundity genes affecting ovulation rate in sheep, bone morphogenetic protein-15 (BMP-15), growth and differentiation factor-9 (GDF-9) and BMP receptor-1B (BMPR-1B). In this review, we focus on the use of these sheep genetic models for understanding the role of the BMP system as an intra-ovarian regulator of follicular growth and maturation, and finally, ovulation rate. BioMed Central 2006-04-12 /pmc/articles/PMC1524776/ /pubmed/16611365 http://dx.doi.org/10.1186/1477-7827-4-20 Text en Copyright © 2006 Fabre et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Fabre, Stéphane
Pierre, Alice
Mulsant, Philippe
Bodin, Loys
Di Pasquale, Elisa
Persani, Luca
Monget, Philippe
Monniaux, Danielle
Regulation of ovulation rate in mammals: contribution of sheep genetic models
title Regulation of ovulation rate in mammals: contribution of sheep genetic models
title_full Regulation of ovulation rate in mammals: contribution of sheep genetic models
title_fullStr Regulation of ovulation rate in mammals: contribution of sheep genetic models
title_full_unstemmed Regulation of ovulation rate in mammals: contribution of sheep genetic models
title_short Regulation of ovulation rate in mammals: contribution of sheep genetic models
title_sort regulation of ovulation rate in mammals: contribution of sheep genetic models
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1524776/
https://www.ncbi.nlm.nih.gov/pubmed/16611365
http://dx.doi.org/10.1186/1477-7827-4-20
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