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Synthesis and properties of 4′-ThioDNA: unexpected RNA-like behavior of 4′-ThioDNA
The synthesis and properties of fully modified 4′-thioDNAs, oligonucleotides consisting of 2′-deoxy-4′-thionucleosides, were examined. In addition to the known literature properties (preferable hybridization with RNA and resistance to endonuclease hydrolysis), we also observed higher resistance of 4...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2006
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1524900/ https://www.ncbi.nlm.nih.gov/pubmed/16855286 http://dx.doi.org/10.1093/nar/gkl491 |