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Melatonin Reduces Inflammatory Injury Through Inhibiting NF-κB Activation in Rats With Colitis

Proinflammatory mediators are important in the pathogenesis of IBD, which are regulated by activation of NF-κB. The aim of this study was to investigate whether melatonin reduces inflammatory injury and inhibits proinflammatory molecule and NF-κB in rats with colitis. Rat colitis model was establish...

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Autores principales: Li, Jun-Hua, Yu, Jie-Ping, Yu, Hong-Gang, Xu, Xi-Ming, Yu, Liang-Liang, Liu, Jin, Luo, He-Sheng
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2005
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1526481/
https://www.ncbi.nlm.nih.gov/pubmed/16192667
http://dx.doi.org/10.1155/MI.2005.185
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author Li, Jun-Hua
Yu, Jie-Ping
Yu, Hong-Gang
Xu, Xi-Ming
Yu, Liang-Liang
Liu, Jin
Luo, He-Sheng
author_facet Li, Jun-Hua
Yu, Jie-Ping
Yu, Hong-Gang
Xu, Xi-Ming
Yu, Liang-Liang
Liu, Jin
Luo, He-Sheng
author_sort Li, Jun-Hua
collection PubMed
description Proinflammatory mediators are important in the pathogenesis of IBD, which are regulated by activation of NF-κB. The aim of this study was to investigate whether melatonin reduces inflammatory injury and inhibits proinflammatory molecule and NF-κB in rats with colitis. Rat colitis model was established by TNBS enema. NF-κB p65, TNF-α, ICAM-1, and IκBαin colon tissue were examined by immunohistochemistry, EMSA, RT-PCR, and Western blot analysis. Expression of proinflammatory molecule and activation of NF-κB were upregulated and IκB level decreased in rats with colitis. Melatonin reduces colonic inflammatory injury through downregulating proinflammatory molecule mediated by NF-κB inhibition and blockade of IκBα degradation.
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spelling pubmed-15264812006-08-21 Melatonin Reduces Inflammatory Injury Through Inhibiting NF-κB Activation in Rats With Colitis Li, Jun-Hua Yu, Jie-Ping Yu, Hong-Gang Xu, Xi-Ming Yu, Liang-Liang Liu, Jin Luo, He-Sheng Mediators Inflamm Research Communication Proinflammatory mediators are important in the pathogenesis of IBD, which are regulated by activation of NF-κB. The aim of this study was to investigate whether melatonin reduces inflammatory injury and inhibits proinflammatory molecule and NF-κB in rats with colitis. Rat colitis model was established by TNBS enema. NF-κB p65, TNF-α, ICAM-1, and IκBαin colon tissue were examined by immunohistochemistry, EMSA, RT-PCR, and Western blot analysis. Expression of proinflammatory molecule and activation of NF-κB were upregulated and IκB level decreased in rats with colitis. Melatonin reduces colonic inflammatory injury through downregulating proinflammatory molecule mediated by NF-κB inhibition and blockade of IκBα degradation. Hindawi Publishing Corporation 2005-08-31 /pmc/articles/PMC1526481/ /pubmed/16192667 http://dx.doi.org/10.1155/MI.2005.185 Text en Hindawi Publishing Corporation
spellingShingle Research Communication
Li, Jun-Hua
Yu, Jie-Ping
Yu, Hong-Gang
Xu, Xi-Ming
Yu, Liang-Liang
Liu, Jin
Luo, He-Sheng
Melatonin Reduces Inflammatory Injury Through Inhibiting NF-κB Activation in Rats With Colitis
title Melatonin Reduces Inflammatory Injury Through Inhibiting NF-κB Activation in Rats With Colitis
title_full Melatonin Reduces Inflammatory Injury Through Inhibiting NF-κB Activation in Rats With Colitis
title_fullStr Melatonin Reduces Inflammatory Injury Through Inhibiting NF-κB Activation in Rats With Colitis
title_full_unstemmed Melatonin Reduces Inflammatory Injury Through Inhibiting NF-κB Activation in Rats With Colitis
title_short Melatonin Reduces Inflammatory Injury Through Inhibiting NF-κB Activation in Rats With Colitis
title_sort melatonin reduces inflammatory injury through inhibiting nf-κb activation in rats with colitis
topic Research Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1526481/
https://www.ncbi.nlm.nih.gov/pubmed/16192667
http://dx.doi.org/10.1155/MI.2005.185
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