Serotonergic Mechanisms Influence the Response to Glucocorticoid Treatment in TMJ Arthritis

The aims of this study were to investigate the influence of serotonin (5-HT) on the effects of intra-articular injections of glucocorticoid on pain of the temporomandibular joint (TMJ) in patients with inflammatory disorders of the TMJ. The pretreatment synovial fluid 5-HT was negatively, and plasma...

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Detalles Bibliográficos
Autores principales: Fredriksson, Lars, Alstergren, Per, Kopp, Sigvard
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2005
Materias:
Research Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1526482/
https://www.ncbi.nlm.nih.gov/pubmed/16192668
http://dx.doi.org/10.1155/MI.2005.194
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author Fredriksson, Lars
Alstergren, Per
Kopp, Sigvard
author_facet Fredriksson, Lars
Alstergren, Per
Kopp, Sigvard
author_sort Fredriksson, Lars
collection PubMed
description The aims of this study were to investigate the influence of serotonin (5-HT) on the effects of intra-articular injections of glucocorticoid on pain of the temporomandibular joint (TMJ) in patients with inflammatory disorders of the TMJ. The pretreatment synovial fluid 5-HT was negatively, and plasma 5-HT positively, correlated to change in TMJ pain after treatment. The pretreatment plasma 5-HT was positively correlated to change in pressure-pain threshold after treatment. In conclusion, this study shows that local and systemic serotonergic mechanisms partly determine the effect of intra-articular glucocorticoid treatment on TMJ pain in patients with chronic TMJ arthritis of systemic nature, while change in pressure-pain threshold over the TMJ is influenced by systemic serotonergic mechanisms.
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spelling pubmed-15264822006-08-21 Serotonergic Mechanisms Influence the Response to Glucocorticoid Treatment in TMJ Arthritis Fredriksson, Lars Alstergren, Per Kopp, Sigvard Mediators Inflamm Research Communication The aims of this study were to investigate the influence of serotonin (5-HT) on the effects of intra-articular injections of glucocorticoid on pain of the temporomandibular joint (TMJ) in patients with inflammatory disorders of the TMJ. The pretreatment synovial fluid 5-HT was negatively, and plasma 5-HT positively, correlated to change in TMJ pain after treatment. The pretreatment plasma 5-HT was positively correlated to change in pressure-pain threshold after treatment. In conclusion, this study shows that local and systemic serotonergic mechanisms partly determine the effect of intra-articular glucocorticoid treatment on TMJ pain in patients with chronic TMJ arthritis of systemic nature, while change in pressure-pain threshold over the TMJ is influenced by systemic serotonergic mechanisms. Hindawi Publishing Corporation 2005-08-31 /pmc/articles/PMC1526482/ /pubmed/16192668 http://dx.doi.org/10.1155/MI.2005.194 Text en Hindawi Publishing Corporation
spellingShingle Research Communication
Fredriksson, Lars
Alstergren, Per
Kopp, Sigvard
Serotonergic Mechanisms Influence the Response to Glucocorticoid Treatment in TMJ Arthritis
title Serotonergic Mechanisms Influence the Response to Glucocorticoid Treatment in TMJ Arthritis
title_full Serotonergic Mechanisms Influence the Response to Glucocorticoid Treatment in TMJ Arthritis
title_fullStr Serotonergic Mechanisms Influence the Response to Glucocorticoid Treatment in TMJ Arthritis
title_full_unstemmed Serotonergic Mechanisms Influence the Response to Glucocorticoid Treatment in TMJ Arthritis
title_short Serotonergic Mechanisms Influence the Response to Glucocorticoid Treatment in TMJ Arthritis
title_sort serotonergic mechanisms influence the response to glucocorticoid treatment in tmj arthritis
topic Research Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1526482/
https://www.ncbi.nlm.nih.gov/pubmed/16192668
http://dx.doi.org/10.1155/MI.2005.194
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