Association of functional variants of PTPN22 and tp53 in psoriatic arthritis: a case-control study

Recent studies have implicated PTPN22 and tp53 in susceptibility to several autoimmune diseases, including rheumatoid arthritis, suggesting that these genes are important in maintaining immune homeostasis. Because autoimmune diseases may share similar susceptibility loci, investigation of these gene...

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Autores principales: Butt, Christopher, Peddle, Lynette, Greenwood, Celia, Hamilton, Sean, Gladman, Dafna, Rahman, Proton
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1526561/
https://www.ncbi.nlm.nih.gov/pubmed/16507123
http://dx.doi.org/10.1186/ar1880
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author Butt, Christopher
Peddle, Lynette
Greenwood, Celia
Hamilton, Sean
Gladman, Dafna
Rahman, Proton
author_facet Butt, Christopher
Peddle, Lynette
Greenwood, Celia
Hamilton, Sean
Gladman, Dafna
Rahman, Proton
author_sort Butt, Christopher
collection PubMed
description Recent studies have implicated PTPN22 and tp53 in susceptibility to several autoimmune diseases, including rheumatoid arthritis, suggesting that these genes are important in maintaining immune homeostasis. Because autoimmune diseases may share similar susceptibility loci, investigation of these genes in psoriatic arthritis (PsA) is of potential relevance. As a result we investigated known coding polymorphisms in PTPN22 and tp53 in a homogenous Caucasian PsA cohort from Newfoundland, Canada and an admixed Caucasian PsA cohort from Toronto, Canada. We observed a moderate association of the R620W variant of PTPN22 with PsA in the Toronto population only. Because of the conflicting findings reported regarding the association of PTPN22 with PsA, further studies in other PsA populations are warranted.
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spelling pubmed-15265612006-08-04 Association of functional variants of PTPN22 and tp53 in psoriatic arthritis: a case-control study Butt, Christopher Peddle, Lynette Greenwood, Celia Hamilton, Sean Gladman, Dafna Rahman, Proton Arthritis Res Ther Research Article Recent studies have implicated PTPN22 and tp53 in susceptibility to several autoimmune diseases, including rheumatoid arthritis, suggesting that these genes are important in maintaining immune homeostasis. Because autoimmune diseases may share similar susceptibility loci, investigation of these genes in psoriatic arthritis (PsA) is of potential relevance. As a result we investigated known coding polymorphisms in PTPN22 and tp53 in a homogenous Caucasian PsA cohort from Newfoundland, Canada and an admixed Caucasian PsA cohort from Toronto, Canada. We observed a moderate association of the R620W variant of PTPN22 with PsA in the Toronto population only. Because of the conflicting findings reported regarding the association of PTPN22 with PsA, further studies in other PsA populations are warranted. BioMed Central 2006 2006-01-03 /pmc/articles/PMC1526561/ /pubmed/16507123 http://dx.doi.org/10.1186/ar1880 Text en Copyright © 2006 Butt et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Butt, Christopher
Peddle, Lynette
Greenwood, Celia
Hamilton, Sean
Gladman, Dafna
Rahman, Proton
Association of functional variants of PTPN22 and tp53 in psoriatic arthritis: a case-control study
title Association of functional variants of PTPN22 and tp53 in psoriatic arthritis: a case-control study
title_full Association of functional variants of PTPN22 and tp53 in psoriatic arthritis: a case-control study
title_fullStr Association of functional variants of PTPN22 and tp53 in psoriatic arthritis: a case-control study
title_full_unstemmed Association of functional variants of PTPN22 and tp53 in psoriatic arthritis: a case-control study
title_short Association of functional variants of PTPN22 and tp53 in psoriatic arthritis: a case-control study
title_sort association of functional variants of ptpn22 and tp53 in psoriatic arthritis: a case-control study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1526561/
https://www.ncbi.nlm.nih.gov/pubmed/16507123
http://dx.doi.org/10.1186/ar1880
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