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Functional inhibition of NF-κB signal transduction in αvβ3 integrin expressing endothelial cells by using RGD-PEG-modified adenovirus with a mutant IκB gene

In order to selectively block nuclear factor κB (NF-κB)-dependent signal transduction in angiogenic endothelial cells, we constructed an αvβ3 integrin specific adenovirus encoding dominant negative IκB (dnIκB) as a therapeutic gene. By virtue of RGD modification of the PEGylated virus, the specifici...

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Detalles Bibliográficos
Autores principales:	Ogawara, Ken-ichi, Kułdo, Joanna M, Oosterhuis, Koen, Kroesen, Bart-Jan, Rots, Marianne G, Trautwein, Christian, Kimura, Toshikiro, Haisma, Hidde J, Molema, Grietje
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2006
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1526577/ https://www.ncbi.nlm.nih.gov/pubmed/16803639 http://dx.doi.org/10.1186/ar1885

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