The in vivo expression of actin/salt-resistant hyperactive DNase I inhibits the development of anti-ssDNA and anti-histone autoantibodies in a murine model of systemic lupus erythematosus

Systemic lupus erythematosus (SLE) is characterised by the production of autoantibodies against ubiquitous antigens, especially nuclear components. Evidence makes it clear that the development of these autoantibodies is an antigen-driven process and that immune complexes involving DNA-containing ant...

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Detalles Bibliográficos
Autores principales: Manderson, Anthony P, Carlucci, Francesco, Lachmann, Peter J, Lazarus, Robert A, Festenstein, Richard J, Cook, H Terence, Walport, Mark J, Botto, Marina
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1526614/
https://www.ncbi.nlm.nih.gov/pubmed/16606442
http://dx.doi.org/10.1186/ar1936

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