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The integrated exposure uptake biokinetic model for lead in children: independent validation and verification.

The U.S. Environmental Protection Agency employs a model, the integrated exposure biokinetic (IEUBK) model for lead in children, for the assessment of risks to children posed by environmental lead at hazardous waste sites. This paper describes results of an effort to verify the consistency of the do...

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Detalles Bibliográficos
Autores principales: Zaragoza, L, Hogan, K
Formato: Texto
Lenguaje:English
Publicado: 1998
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1533463/
https://www.ncbi.nlm.nih.gov/pubmed/9860914
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author Zaragoza, L
Hogan, K
author_facet Zaragoza, L
Hogan, K
author_sort Zaragoza, L
collection PubMed
description The U.S. Environmental Protection Agency employs a model, the integrated exposure biokinetic (IEUBK) model for lead in children, for the assessment of risks to children posed by environmental lead at hazardous waste sites. This paper describes results of an effort to verify the consistency of the documentation with the computer model and to test the computer code using a group that is independent from those involved in the model development. This review concluded that the IEUBK model correctly calculates the equations specified in the IEUBK model theory documentation. However, several issues were identified on model documentation, model performance, and the C++ programming language code (i.e., IEUBK model source code) documentation. These issues affect the ability of an independent reviewer to understand the workings of the IEUBK model but not the model's reliability. As a result of these findings, recommendations have been provided for updating documentation to the model as well as associated adjustments to the model documentation.
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spelling pubmed-15334632006-08-08 The integrated exposure uptake biokinetic model for lead in children: independent validation and verification. Zaragoza, L Hogan, K Environ Health Perspect Research Article The U.S. Environmental Protection Agency employs a model, the integrated exposure biokinetic (IEUBK) model for lead in children, for the assessment of risks to children posed by environmental lead at hazardous waste sites. This paper describes results of an effort to verify the consistency of the documentation with the computer model and to test the computer code using a group that is independent from those involved in the model development. This review concluded that the IEUBK model correctly calculates the equations specified in the IEUBK model theory documentation. However, several issues were identified on model documentation, model performance, and the C++ programming language code (i.e., IEUBK model source code) documentation. These issues affect the ability of an independent reviewer to understand the workings of the IEUBK model but not the model's reliability. As a result of these findings, recommendations have been provided for updating documentation to the model as well as associated adjustments to the model documentation. 1998-12 /pmc/articles/PMC1533463/ /pubmed/9860914 Text en
spellingShingle Research Article
Zaragoza, L
Hogan, K
The integrated exposure uptake biokinetic model for lead in children: independent validation and verification.
title The integrated exposure uptake biokinetic model for lead in children: independent validation and verification.
title_full The integrated exposure uptake biokinetic model for lead in children: independent validation and verification.
title_fullStr The integrated exposure uptake biokinetic model for lead in children: independent validation and verification.
title_full_unstemmed The integrated exposure uptake biokinetic model for lead in children: independent validation and verification.
title_short The integrated exposure uptake biokinetic model for lead in children: independent validation and verification.
title_sort integrated exposure uptake biokinetic model for lead in children: independent validation and verification.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1533463/
https://www.ncbi.nlm.nih.gov/pubmed/9860914
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