Repeated Doses of UVR Cause Minor Alteration in Cytokine Serum Levels in Humans

The aim of our study was to compare serum concentration of IL-1β, IL-6, IL-8, IL-10, and TNF-α in 105 healthy volunteers before and after exposure to UVR: 25 subjects (10 days of UVB), 55 (10 days of UVB or solar-simulated radiation, followed by acute UVB dose), and 25 (local high dose of UVB). In a...

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Detalles Bibliográficos
Autores principales: Narbutt, Joanna, Lesiak, Aleksandra, Skibinska, Malgorzata, Wozniacka, Anna, Sysa-Jedrzejowska, Anna, Lukamowicz, Joalanta, van Loveren, Henk
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2005
Materias:
Research Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1533891/
https://www.ncbi.nlm.nih.gov/pubmed/16258197
http://dx.doi.org/10.1155/MI.2005.298
Descripción
Sumario:The aim of our study was to compare serum concentration of IL-1β, IL-6, IL-8, IL-10, and TNF-α in 105 healthy volunteers before and after exposure to UVR: 25 subjects (10 days of UVB), 55 (10 days of UVB or solar-simulated radiation, followed by acute UVB dose), and 25 (local high dose of UVB). In all the individuals blood samples were analyzed before and after final irradiation by chemiluminescence assay. After 10 days of UVB irradiation a statistically significant increase in serum concentration only in IL-8 (P < .05) and strong tendency in TNF-α (P = .05) were observed. The applied schedules of irradiation have minor impact on serum cytokine level and still a threshold dose of UVR causing systemic immune impairment is unknown.

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