Repeated Doses of UVR Cause Minor Alteration in Cytokine Serum Levels in Humans

The aim of our study was to compare serum concentration of IL-1β, IL-6, IL-8, IL-10, and TNF-α in 105 healthy volunteers before and after exposure to UVR: 25 subjects (10 days of UVB), 55 (10 days of UVB or solar-simulated radiation, followed by acute UVB dose), and 25 (local high dose of UVB). In a...

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Autores principales: Narbutt, Joanna, Lesiak, Aleksandra, Skibinska, Malgorzata, Wozniacka, Anna, Sysa-Jedrzejowska, Anna, Lukamowicz, Joalanta, van Loveren, Henk
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2005
Materias:
Research Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1533891/
https://www.ncbi.nlm.nih.gov/pubmed/16258197
http://dx.doi.org/10.1155/MI.2005.298
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author Narbutt, Joanna
Lesiak, Aleksandra
Skibinska, Malgorzata
Wozniacka, Anna
Sysa-Jedrzejowska, Anna
Lukamowicz, Joalanta
van Loveren, Henk
author_facet Narbutt, Joanna
Lesiak, Aleksandra
Skibinska, Malgorzata
Wozniacka, Anna
Sysa-Jedrzejowska, Anna
Lukamowicz, Joalanta
van Loveren, Henk
author_sort Narbutt, Joanna
collection PubMed
description The aim of our study was to compare serum concentration of IL-1β, IL-6, IL-8, IL-10, and TNF-α in 105 healthy volunteers before and after exposure to UVR: 25 subjects (10 days of UVB), 55 (10 days of UVB or solar-simulated radiation, followed by acute UVB dose), and 25 (local high dose of UVB). In all the individuals blood samples were analyzed before and after final irradiation by chemiluminescence assay. After 10 days of UVB irradiation a statistically significant increase in serum concentration only in IL-8 (P < .05) and strong tendency in TNF-α (P = .05) were observed. The applied schedules of irradiation have minor impact on serum cytokine level and still a threshold dose of UVR causing systemic immune impairment is unknown.
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spelling pubmed-15338912006-08-21 Repeated Doses of UVR Cause Minor Alteration in Cytokine Serum Levels in Humans Narbutt, Joanna Lesiak, Aleksandra Skibinska, Malgorzata Wozniacka, Anna Sysa-Jedrzejowska, Anna Lukamowicz, Joalanta van Loveren, Henk Mediators Inflamm Research Communication The aim of our study was to compare serum concentration of IL-1β, IL-6, IL-8, IL-10, and TNF-α in 105 healthy volunteers before and after exposure to UVR: 25 subjects (10 days of UVB), 55 (10 days of UVB or solar-simulated radiation, followed by acute UVB dose), and 25 (local high dose of UVB). In all the individuals blood samples were analyzed before and after final irradiation by chemiluminescence assay. After 10 days of UVB irradiation a statistically significant increase in serum concentration only in IL-8 (P < .05) and strong tendency in TNF-α (P = .05) were observed. The applied schedules of irradiation have minor impact on serum cytokine level and still a threshold dose of UVR causing systemic immune impairment is unknown. Hindawi Publishing Corporation 2005-10-24 /pmc/articles/PMC1533891/ /pubmed/16258197 http://dx.doi.org/10.1155/MI.2005.298 Text en Hindawi Publishing Corporation
spellingShingle Research Communication
Narbutt, Joanna
Lesiak, Aleksandra
Skibinska, Malgorzata
Wozniacka, Anna
Sysa-Jedrzejowska, Anna
Lukamowicz, Joalanta
van Loveren, Henk
Repeated Doses of UVR Cause Minor Alteration in Cytokine Serum Levels in Humans
title Repeated Doses of UVR Cause Minor Alteration in Cytokine Serum Levels in Humans
title_full Repeated Doses of UVR Cause Minor Alteration in Cytokine Serum Levels in Humans
title_fullStr Repeated Doses of UVR Cause Minor Alteration in Cytokine Serum Levels in Humans
title_full_unstemmed Repeated Doses of UVR Cause Minor Alteration in Cytokine Serum Levels in Humans
title_short Repeated Doses of UVR Cause Minor Alteration in Cytokine Serum Levels in Humans
title_sort repeated doses of uvr cause minor alteration in cytokine serum levels in humans
topic Research Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1533891/
https://www.ncbi.nlm.nih.gov/pubmed/16258197
http://dx.doi.org/10.1155/MI.2005.298
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