Cargando…

The Imbalance Between Metalloproteinases and Their Tissue Inhibitors Is Involved in the Pathogenesis of Dermatitis Herpetiformis

Dermatitis herpetiformis (DH) is a subepidermal autoimmune disease characterized by skin and intestinal lesions consistent with coeliac disease. There are also some data that metalloproteinases (MMPs) are involved in the development of skin lesions in DH, however their exact role in this process is...

Descripción completa

Detalles Bibliográficos
Autores principales: Zebrowska, Agnieszka, Narbutt, Joanna, Sysa-Jedrzejowska, Anna, Kobos, Jozef, Waszczykowska, Elzbieta
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2005
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1533900/
https://www.ncbi.nlm.nih.gov/pubmed/16489258
http://dx.doi.org/10.1155/MI.2005.373
_version_ 1782129080978636800
author Zebrowska, Agnieszka
Narbutt, Joanna
Sysa-Jedrzejowska, Anna
Kobos, Jozef
Waszczykowska, Elzbieta
author_facet Zebrowska, Agnieszka
Narbutt, Joanna
Sysa-Jedrzejowska, Anna
Kobos, Jozef
Waszczykowska, Elzbieta
author_sort Zebrowska, Agnieszka
collection PubMed
description Dermatitis herpetiformis (DH) is a subepidermal autoimmune disease characterized by skin and intestinal lesions consistent with coeliac disease. There are also some data that metalloproteinases (MMPs) are involved in the development of skin lesions in DH, however their exact role in this process is not fully understood. The aim of the study was to investigate whether MMPs and their inhibitors are involved in pathogenesis of DH. Skin biopsies were taken from 13 patients with active DH and from 10 healthy subjects. The localization and expression of MMPs and TIMPs were examined by immunohistochemistry. MMPs expression was detected in basal keratinocytes and in the whole epidermis in all of the DH subjects. Neutrophils in microabscesses and in blister fluid were also positive for MMPs. Expression of TIMPs was moderate or weak in all examined biopsies. Our results allow us to conclude that imbalance between these enzymes takes an important role in the pathogenesis of DH.
format Text
id pubmed-1533900
institution National Center for Biotechnology Information
language English
publishDate 2005
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-15339002006-08-23 The Imbalance Between Metalloproteinases and Their Tissue Inhibitors Is Involved in the Pathogenesis of Dermatitis Herpetiformis Zebrowska, Agnieszka Narbutt, Joanna Sysa-Jedrzejowska, Anna Kobos, Jozef Waszczykowska, Elzbieta Mediators Inflamm Research Communication Dermatitis herpetiformis (DH) is a subepidermal autoimmune disease characterized by skin and intestinal lesions consistent with coeliac disease. There are also some data that metalloproteinases (MMPs) are involved in the development of skin lesions in DH, however their exact role in this process is not fully understood. The aim of the study was to investigate whether MMPs and their inhibitors are involved in pathogenesis of DH. Skin biopsies were taken from 13 patients with active DH and from 10 healthy subjects. The localization and expression of MMPs and TIMPs were examined by immunohistochemistry. MMPs expression was detected in basal keratinocytes and in the whole epidermis in all of the DH subjects. Neutrophils in microabscesses and in blister fluid were also positive for MMPs. Expression of TIMPs was moderate or weak in all examined biopsies. Our results allow us to conclude that imbalance between these enzymes takes an important role in the pathogenesis of DH. Hindawi Publishing Corporation 2005-12-14 /pmc/articles/PMC1533900/ /pubmed/16489258 http://dx.doi.org/10.1155/MI.2005.373 Text en Hindawi Publishing Corporation
spellingShingle Research Communication
Zebrowska, Agnieszka
Narbutt, Joanna
Sysa-Jedrzejowska, Anna
Kobos, Jozef
Waszczykowska, Elzbieta
The Imbalance Between Metalloproteinases and Their Tissue Inhibitors Is Involved in the Pathogenesis of Dermatitis Herpetiformis
title The Imbalance Between Metalloproteinases and Their Tissue Inhibitors Is Involved in the Pathogenesis of Dermatitis Herpetiformis
title_full The Imbalance Between Metalloproteinases and Their Tissue Inhibitors Is Involved in the Pathogenesis of Dermatitis Herpetiformis
title_fullStr The Imbalance Between Metalloproteinases and Their Tissue Inhibitors Is Involved in the Pathogenesis of Dermatitis Herpetiformis
title_full_unstemmed The Imbalance Between Metalloproteinases and Their Tissue Inhibitors Is Involved in the Pathogenesis of Dermatitis Herpetiformis
title_short The Imbalance Between Metalloproteinases and Their Tissue Inhibitors Is Involved in the Pathogenesis of Dermatitis Herpetiformis
title_sort imbalance between metalloproteinases and their tissue inhibitors is involved in the pathogenesis of dermatitis herpetiformis
topic Research Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1533900/
https://www.ncbi.nlm.nih.gov/pubmed/16489258
http://dx.doi.org/10.1155/MI.2005.373
work_keys_str_mv AT zebrowskaagnieszka theimbalancebetweenmetalloproteinasesandtheirtissueinhibitorsisinvolvedinthepathogenesisofdermatitisherpetiformis
AT narbuttjoanna theimbalancebetweenmetalloproteinasesandtheirtissueinhibitorsisinvolvedinthepathogenesisofdermatitisherpetiformis
AT sysajedrzejowskaanna theimbalancebetweenmetalloproteinasesandtheirtissueinhibitorsisinvolvedinthepathogenesisofdermatitisherpetiformis
AT kobosjozef theimbalancebetweenmetalloproteinasesandtheirtissueinhibitorsisinvolvedinthepathogenesisofdermatitisherpetiformis
AT waszczykowskaelzbieta theimbalancebetweenmetalloproteinasesandtheirtissueinhibitorsisinvolvedinthepathogenesisofdermatitisherpetiformis
AT zebrowskaagnieszka imbalancebetweenmetalloproteinasesandtheirtissueinhibitorsisinvolvedinthepathogenesisofdermatitisherpetiformis
AT narbuttjoanna imbalancebetweenmetalloproteinasesandtheirtissueinhibitorsisinvolvedinthepathogenesisofdermatitisherpetiformis
AT sysajedrzejowskaanna imbalancebetweenmetalloproteinasesandtheirtissueinhibitorsisinvolvedinthepathogenesisofdermatitisherpetiformis
AT kobosjozef imbalancebetweenmetalloproteinasesandtheirtissueinhibitorsisinvolvedinthepathogenesisofdermatitisherpetiformis
AT waszczykowskaelzbieta imbalancebetweenmetalloproteinasesandtheirtissueinhibitorsisinvolvedinthepathogenesisofdermatitisherpetiformis