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Reference values for exhaled nitric oxide (reveno) study

BACKGROUND: Despite the widespread use of fractional exhaled nitric oxide (FE(NO)) as a biomarker of airways inflammation, there are no published papers describing normal FE(NO )values in a large group of healthy adults. OBJECTIVE: The aim of this study was to establish adult FE(NO )reference values...

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Autores principales: Olivieri, Mario, Talamini, Giorgio, Corradi, Massimo, Perbellini, Luigi, Mutti, Antonio, Tantucci, Claudio, Malerba, Mario
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1534026/
https://www.ncbi.nlm.nih.gov/pubmed/16813647
http://dx.doi.org/10.1186/1465-9921-7-94
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author Olivieri, Mario
Talamini, Giorgio
Corradi, Massimo
Perbellini, Luigi
Mutti, Antonio
Tantucci, Claudio
Malerba, Mario
author_facet Olivieri, Mario
Talamini, Giorgio
Corradi, Massimo
Perbellini, Luigi
Mutti, Antonio
Tantucci, Claudio
Malerba, Mario
author_sort Olivieri, Mario
collection PubMed
description BACKGROUND: Despite the widespread use of fractional exhaled nitric oxide (FE(NO)) as a biomarker of airways inflammation, there are no published papers describing normal FE(NO )values in a large group of healthy adults. OBJECTIVE: The aim of this study was to establish adult FE(NO )reference values according to the international guidelines. METHODS: FE(NO )was measured in 204 healthy, non-smoking adults with normal spirometry values using the on-line single-breath technique, and the results were analysed chemiluminescently. RESULTS: The main result of the study was the significant difference in FE(NO )values between men and women, thus indicating that gender-based reference FE(NO )values are necessary. The FE(NO )levels obtained at expiratory flows of 50 ml/s ranged from 2.6 to 28.8 ppb in men, and from 1.6 to 21.5 ppb in women. CONCLUSION: We propose reference FE(NO )values for healthy adult men and women that could be used for clinical and research purposes.
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spelling pubmed-15340262006-08-09 Reference values for exhaled nitric oxide (reveno) study Olivieri, Mario Talamini, Giorgio Corradi, Massimo Perbellini, Luigi Mutti, Antonio Tantucci, Claudio Malerba, Mario Respir Res Research BACKGROUND: Despite the widespread use of fractional exhaled nitric oxide (FE(NO)) as a biomarker of airways inflammation, there are no published papers describing normal FE(NO )values in a large group of healthy adults. OBJECTIVE: The aim of this study was to establish adult FE(NO )reference values according to the international guidelines. METHODS: FE(NO )was measured in 204 healthy, non-smoking adults with normal spirometry values using the on-line single-breath technique, and the results were analysed chemiluminescently. RESULTS: The main result of the study was the significant difference in FE(NO )values between men and women, thus indicating that gender-based reference FE(NO )values are necessary. The FE(NO )levels obtained at expiratory flows of 50 ml/s ranged from 2.6 to 28.8 ppb in men, and from 1.6 to 21.5 ppb in women. CONCLUSION: We propose reference FE(NO )values for healthy adult men and women that could be used for clinical and research purposes. BioMed Central 2006 2006-06-30 /pmc/articles/PMC1534026/ /pubmed/16813647 http://dx.doi.org/10.1186/1465-9921-7-94 Text en Copyright © 2006 Olivieri et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Olivieri, Mario
Talamini, Giorgio
Corradi, Massimo
Perbellini, Luigi
Mutti, Antonio
Tantucci, Claudio
Malerba, Mario
Reference values for exhaled nitric oxide (reveno) study
title Reference values for exhaled nitric oxide (reveno) study
title_full Reference values for exhaled nitric oxide (reveno) study
title_fullStr Reference values for exhaled nitric oxide (reveno) study
title_full_unstemmed Reference values for exhaled nitric oxide (reveno) study
title_short Reference values for exhaled nitric oxide (reveno) study
title_sort reference values for exhaled nitric oxide (reveno) study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1534026/
https://www.ncbi.nlm.nih.gov/pubmed/16813647
http://dx.doi.org/10.1186/1465-9921-7-94
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