Cargando…
Reference values for exhaled nitric oxide (reveno) study
BACKGROUND: Despite the widespread use of fractional exhaled nitric oxide (FE(NO)) as a biomarker of airways inflammation, there are no published papers describing normal FE(NO )values in a large group of healthy adults. OBJECTIVE: The aim of this study was to establish adult FE(NO )reference values...
Autores principales: | , , , , , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2006
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1534026/ https://www.ncbi.nlm.nih.gov/pubmed/16813647 http://dx.doi.org/10.1186/1465-9921-7-94 |
_version_ | 1782129089838055424 |
---|---|
author | Olivieri, Mario Talamini, Giorgio Corradi, Massimo Perbellini, Luigi Mutti, Antonio Tantucci, Claudio Malerba, Mario |
author_facet | Olivieri, Mario Talamini, Giorgio Corradi, Massimo Perbellini, Luigi Mutti, Antonio Tantucci, Claudio Malerba, Mario |
author_sort | Olivieri, Mario |
collection | PubMed |
description | BACKGROUND: Despite the widespread use of fractional exhaled nitric oxide (FE(NO)) as a biomarker of airways inflammation, there are no published papers describing normal FE(NO )values in a large group of healthy adults. OBJECTIVE: The aim of this study was to establish adult FE(NO )reference values according to the international guidelines. METHODS: FE(NO )was measured in 204 healthy, non-smoking adults with normal spirometry values using the on-line single-breath technique, and the results were analysed chemiluminescently. RESULTS: The main result of the study was the significant difference in FE(NO )values between men and women, thus indicating that gender-based reference FE(NO )values are necessary. The FE(NO )levels obtained at expiratory flows of 50 ml/s ranged from 2.6 to 28.8 ppb in men, and from 1.6 to 21.5 ppb in women. CONCLUSION: We propose reference FE(NO )values for healthy adult men and women that could be used for clinical and research purposes. |
format | Text |
id | pubmed-1534026 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2006 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-15340262006-08-09 Reference values for exhaled nitric oxide (reveno) study Olivieri, Mario Talamini, Giorgio Corradi, Massimo Perbellini, Luigi Mutti, Antonio Tantucci, Claudio Malerba, Mario Respir Res Research BACKGROUND: Despite the widespread use of fractional exhaled nitric oxide (FE(NO)) as a biomarker of airways inflammation, there are no published papers describing normal FE(NO )values in a large group of healthy adults. OBJECTIVE: The aim of this study was to establish adult FE(NO )reference values according to the international guidelines. METHODS: FE(NO )was measured in 204 healthy, non-smoking adults with normal spirometry values using the on-line single-breath technique, and the results were analysed chemiluminescently. RESULTS: The main result of the study was the significant difference in FE(NO )values between men and women, thus indicating that gender-based reference FE(NO )values are necessary. The FE(NO )levels obtained at expiratory flows of 50 ml/s ranged from 2.6 to 28.8 ppb in men, and from 1.6 to 21.5 ppb in women. CONCLUSION: We propose reference FE(NO )values for healthy adult men and women that could be used for clinical and research purposes. BioMed Central 2006 2006-06-30 /pmc/articles/PMC1534026/ /pubmed/16813647 http://dx.doi.org/10.1186/1465-9921-7-94 Text en Copyright © 2006 Olivieri et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Olivieri, Mario Talamini, Giorgio Corradi, Massimo Perbellini, Luigi Mutti, Antonio Tantucci, Claudio Malerba, Mario Reference values for exhaled nitric oxide (reveno) study |
title | Reference values for exhaled nitric oxide (reveno) study |
title_full | Reference values for exhaled nitric oxide (reveno) study |
title_fullStr | Reference values for exhaled nitric oxide (reveno) study |
title_full_unstemmed | Reference values for exhaled nitric oxide (reveno) study |
title_short | Reference values for exhaled nitric oxide (reveno) study |
title_sort | reference values for exhaled nitric oxide (reveno) study |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1534026/ https://www.ncbi.nlm.nih.gov/pubmed/16813647 http://dx.doi.org/10.1186/1465-9921-7-94 |
work_keys_str_mv | AT olivierimario referencevaluesforexhalednitricoxiderevenostudy AT talaminigiorgio referencevaluesforexhalednitricoxiderevenostudy AT corradimassimo referencevaluesforexhalednitricoxiderevenostudy AT perbelliniluigi referencevaluesforexhalednitricoxiderevenostudy AT muttiantonio referencevaluesforexhalednitricoxiderevenostudy AT tantucciclaudio referencevaluesforexhalednitricoxiderevenostudy AT malerbamario referencevaluesforexhalednitricoxiderevenostudy |