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ALK1 signalling analysis identifies angiogenesis related genes and reveals disparity between TGF-β and constitutively active receptor induced gene expression

BACKGROUND: TGF-β1 is an important angiogenic factor involved in the different aspects of angiogenesis and vessel maintenance. TGF-β signalling is mediated by the TβRII/ALK5 receptor complex activating the Smad2/Smad3 pathway. In endothelial cells TGF-β utilizes a second type I receptor, ALK1, activ...

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Detalles Bibliográficos
Autores principales:	Lux, Andreas, Salway, Fiona, Dressman, Holly K, Kröner-Lux, Gabriele, Hafner, Mathias, Day, Philip JR, Marchuk, Douglas A, Garland, John
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2006
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1534055/ https://www.ncbi.nlm.nih.gov/pubmed/16594992 http://dx.doi.org/10.1186/1471-2261-6-13

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