Cargando…

Influence of flow on mucosal-to-arterial carbon dioxide difference

Intramucosal-to-arterial carbon dioxide difference (the so-called PCO(2) [partial carbon dioxide tension] gap) remains largely unaltered during decreased oxygen delivery, if the latter is reduced as flow is maintained. In this condition (hypoxic hypoxia or anaemic hypoxia), the PCO(2) gap fails to m...

Descripción completa

Detalles Bibliográficos
Autor principal: Vallet, Benoit
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2002
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC153447/
https://www.ncbi.nlm.nih.gov/pubmed/12493063
http://dx.doi.org/10.1186/cc1845
_version_ 1782120701652631552
author Vallet, Benoit
author_facet Vallet, Benoit
author_sort Vallet, Benoit
collection PubMed
description Intramucosal-to-arterial carbon dioxide difference (the so-called PCO(2) [partial carbon dioxide tension] gap) remains largely unaltered during decreased oxygen delivery, if the latter is reduced as flow is maintained. In this condition (hypoxic hypoxia or anaemic hypoxia), the PCO(2) gap fails to mirror intestinal tissue dysoxia. Results from several experiments have demonstrated that blood flow is the main determinant of PCO(2) gap. Gastrointestinal tonometry is clearly a useful indirect method for monitoring perfusion, but it has rather limited value in detecting anaerobic metabolism when blood flow is preserved. These considerations render it very unlikely that PCO(2) may dramatically increase (or that intramucosal pH may decrease) in any hypoxic state with preserved flow.
format Text
id pubmed-153447
institution National Center for Biotechnology Information
language English
publishDate 2002
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-1534472003-04-18 Influence of flow on mucosal-to-arterial carbon dioxide difference Vallet, Benoit Crit Care Commentary Intramucosal-to-arterial carbon dioxide difference (the so-called PCO(2) [partial carbon dioxide tension] gap) remains largely unaltered during decreased oxygen delivery, if the latter is reduced as flow is maintained. In this condition (hypoxic hypoxia or anaemic hypoxia), the PCO(2) gap fails to mirror intestinal tissue dysoxia. Results from several experiments have demonstrated that blood flow is the main determinant of PCO(2) gap. Gastrointestinal tonometry is clearly a useful indirect method for monitoring perfusion, but it has rather limited value in detecting anaerobic metabolism when blood flow is preserved. These considerations render it very unlikely that PCO(2) may dramatically increase (or that intramucosal pH may decrease) in any hypoxic state with preserved flow. BioMed Central 2002 2002-11-01 /pmc/articles/PMC153447/ /pubmed/12493063 http://dx.doi.org/10.1186/cc1845 Text en Copyright © 2002 BioMed Central Ltd
spellingShingle Commentary
Vallet, Benoit
Influence of flow on mucosal-to-arterial carbon dioxide difference
title Influence of flow on mucosal-to-arterial carbon dioxide difference
title_full Influence of flow on mucosal-to-arterial carbon dioxide difference
title_fullStr Influence of flow on mucosal-to-arterial carbon dioxide difference
title_full_unstemmed Influence of flow on mucosal-to-arterial carbon dioxide difference
title_short Influence of flow on mucosal-to-arterial carbon dioxide difference
title_sort influence of flow on mucosal-to-arterial carbon dioxide difference
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC153447/
https://www.ncbi.nlm.nih.gov/pubmed/12493063
http://dx.doi.org/10.1186/cc1845
work_keys_str_mv AT valletbenoit influenceofflowonmucosaltoarterialcarbondioxidedifference