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Influence of flow on mucosal-to-arterial carbon dioxide difference
Intramucosal-to-arterial carbon dioxide difference (the so-called PCO(2) [partial carbon dioxide tension] gap) remains largely unaltered during decreased oxygen delivery, if the latter is reduced as flow is maintained. In this condition (hypoxic hypoxia or anaemic hypoxia), the PCO(2) gap fails to m...
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2002
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC153447/ https://www.ncbi.nlm.nih.gov/pubmed/12493063 http://dx.doi.org/10.1186/cc1845 |
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author | Vallet, Benoit |
author_facet | Vallet, Benoit |
author_sort | Vallet, Benoit |
collection | PubMed |
description | Intramucosal-to-arterial carbon dioxide difference (the so-called PCO(2) [partial carbon dioxide tension] gap) remains largely unaltered during decreased oxygen delivery, if the latter is reduced as flow is maintained. In this condition (hypoxic hypoxia or anaemic hypoxia), the PCO(2) gap fails to mirror intestinal tissue dysoxia. Results from several experiments have demonstrated that blood flow is the main determinant of PCO(2) gap. Gastrointestinal tonometry is clearly a useful indirect method for monitoring perfusion, but it has rather limited value in detecting anaerobic metabolism when blood flow is preserved. These considerations render it very unlikely that PCO(2) may dramatically increase (or that intramucosal pH may decrease) in any hypoxic state with preserved flow. |
format | Text |
id | pubmed-153447 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2002 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-1534472003-04-18 Influence of flow on mucosal-to-arterial carbon dioxide difference Vallet, Benoit Crit Care Commentary Intramucosal-to-arterial carbon dioxide difference (the so-called PCO(2) [partial carbon dioxide tension] gap) remains largely unaltered during decreased oxygen delivery, if the latter is reduced as flow is maintained. In this condition (hypoxic hypoxia or anaemic hypoxia), the PCO(2) gap fails to mirror intestinal tissue dysoxia. Results from several experiments have demonstrated that blood flow is the main determinant of PCO(2) gap. Gastrointestinal tonometry is clearly a useful indirect method for monitoring perfusion, but it has rather limited value in detecting anaerobic metabolism when blood flow is preserved. These considerations render it very unlikely that PCO(2) may dramatically increase (or that intramucosal pH may decrease) in any hypoxic state with preserved flow. BioMed Central 2002 2002-11-01 /pmc/articles/PMC153447/ /pubmed/12493063 http://dx.doi.org/10.1186/cc1845 Text en Copyright © 2002 BioMed Central Ltd |
spellingShingle | Commentary Vallet, Benoit Influence of flow on mucosal-to-arterial carbon dioxide difference |
title | Influence of flow on mucosal-to-arterial carbon dioxide difference |
title_full | Influence of flow on mucosal-to-arterial carbon dioxide difference |
title_fullStr | Influence of flow on mucosal-to-arterial carbon dioxide difference |
title_full_unstemmed | Influence of flow on mucosal-to-arterial carbon dioxide difference |
title_short | Influence of flow on mucosal-to-arterial carbon dioxide difference |
title_sort | influence of flow on mucosal-to-arterial carbon dioxide difference |
topic | Commentary |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC153447/ https://www.ncbi.nlm.nih.gov/pubmed/12493063 http://dx.doi.org/10.1186/cc1845 |
work_keys_str_mv | AT valletbenoit influenceofflowonmucosaltoarterialcarbondioxidedifference |