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Fragile X (CGG)(n )repeats induce a transcriptional repression in cis upon a linked promoter: Evidence for a chromatin mediated effect

BACKGROUND: Expansion of an unstable (CGG)(n )repeat to over 200 triplets within the promoter region of the human FMR1 gene leads to extensive local methylation and transcription silencing, resulting in the loss of FMRP protein and the development of the clinical features of fragile X syndrome. The...

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Detalles Bibliográficos
Autores principales:	Chandler, Simon P, Kansagra, Pushpa, Hirst, Mark C
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2003
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC153536/ https://www.ncbi.nlm.nih.gov/pubmed/12659659 http://dx.doi.org/10.1186/1471-2199-4-3

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