siVirus: web-based antiviral siRNA design software for highly divergent viral sequences

siVirus () is a web-based online software system that provides efficient short interfering RNA (siRNA) design for antiviral RNA interference (RNAi). siVirus searches for functional, off-target minimized siRNAs targeting highly conserved regions of divergent viral sequences. These siRNAs are expected...

Descripción completa

Detalles Bibliográficos
Autores principales: Naito, Yuki, Ui-Tei, Kumiko, Nishikawa, Toru, Takebe, Yutaka, Saigo, Kaoru
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2006
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1538817/
https://www.ncbi.nlm.nih.gov/pubmed/16845046
http://dx.doi.org/10.1093/nar/gkl214
Descripción
Sumario:siVirus () is a web-based online software system that provides efficient short interfering RNA (siRNA) design for antiviral RNA interference (RNAi). siVirus searches for functional, off-target minimized siRNAs targeting highly conserved regions of divergent viral sequences. These siRNAs are expected to resist viral mutational escape, since their highly conserved targets likely contain structurally/functionally constrained elements. siVirus will be a useful tool for designing optimal siRNAs targeting highly divergent pathogens, including human immunodeficiency virus (HIV), hepatitis C virus (HCV), influenza virus and SARS coronavirus, all of which pose enormous threats to global human health.

Ejemplares similares