siVirus: web-based antiviral siRNA design software for highly divergent viral sequences

siVirus () is a web-based online software system that provides efficient short interfering RNA (siRNA) design for antiviral RNA interference (RNAi). siVirus searches for functional, off-target minimized siRNAs targeting highly conserved regions of divergent viral sequences. These siRNAs are expected...

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Detalles Bibliográficos
Autores principales: Naito, Yuki, Ui-Tei, Kumiko, Nishikawa, Toru, Takebe, Yutaka, Saigo, Kaoru
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2006
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1538817/
https://www.ncbi.nlm.nih.gov/pubmed/16845046
http://dx.doi.org/10.1093/nar/gkl214
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author Naito, Yuki
Ui-Tei, Kumiko
Nishikawa, Toru
Takebe, Yutaka
Saigo, Kaoru
author_facet Naito, Yuki
Ui-Tei, Kumiko
Nishikawa, Toru
Takebe, Yutaka
Saigo, Kaoru
author_sort Naito, Yuki
collection PubMed
description siVirus () is a web-based online software system that provides efficient short interfering RNA (siRNA) design for antiviral RNA interference (RNAi). siVirus searches for functional, off-target minimized siRNAs targeting highly conserved regions of divergent viral sequences. These siRNAs are expected to resist viral mutational escape, since their highly conserved targets likely contain structurally/functionally constrained elements. siVirus will be a useful tool for designing optimal siRNAs targeting highly divergent pathogens, including human immunodeficiency virus (HIV), hepatitis C virus (HCV), influenza virus and SARS coronavirus, all of which pose enormous threats to global human health.
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spelling pubmed-15388172006-08-18 siVirus: web-based antiviral siRNA design software for highly divergent viral sequences Naito, Yuki Ui-Tei, Kumiko Nishikawa, Toru Takebe, Yutaka Saigo, Kaoru Nucleic Acids Res Article siVirus () is a web-based online software system that provides efficient short interfering RNA (siRNA) design for antiviral RNA interference (RNAi). siVirus searches for functional, off-target minimized siRNAs targeting highly conserved regions of divergent viral sequences. These siRNAs are expected to resist viral mutational escape, since their highly conserved targets likely contain structurally/functionally constrained elements. siVirus will be a useful tool for designing optimal siRNAs targeting highly divergent pathogens, including human immunodeficiency virus (HIV), hepatitis C virus (HCV), influenza virus and SARS coronavirus, all of which pose enormous threats to global human health. Oxford University Press 2006-07-01 2006-07-14 /pmc/articles/PMC1538817/ /pubmed/16845046 http://dx.doi.org/10.1093/nar/gkl214 Text en © The Author 2006. Published by Oxford University Press. All rights reserved
spellingShingle Article
Naito, Yuki
Ui-Tei, Kumiko
Nishikawa, Toru
Takebe, Yutaka
Saigo, Kaoru
siVirus: web-based antiviral siRNA design software for highly divergent viral sequences
title siVirus: web-based antiviral siRNA design software for highly divergent viral sequences
title_full siVirus: web-based antiviral siRNA design software for highly divergent viral sequences
title_fullStr siVirus: web-based antiviral siRNA design software for highly divergent viral sequences
title_full_unstemmed siVirus: web-based antiviral siRNA design software for highly divergent viral sequences
title_short siVirus: web-based antiviral siRNA design software for highly divergent viral sequences
title_sort sivirus: web-based antiviral sirna design software for highly divergent viral sequences
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1538817/
https://www.ncbi.nlm.nih.gov/pubmed/16845046
http://dx.doi.org/10.1093/nar/gkl214
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