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Mutation of the phospholipase C-γ1–binding site of LAT affects both positive and negative thymocyte selection
Linker for activation of T cells (LAT) is a scaffolding adaptor protein that is critical for T cell development and function. A mutation of LAT (Y136F) that disrupts phospholipase C-γ1 activation and subsequent calcium influx causes a partial block in T cell development and leads to a severe lymphop...
| Autores principales: | , , , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2005
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1538971/ https://www.ncbi.nlm.nih.gov/pubmed/15795236 http://dx.doi.org/10.1084/jem.20041869 |