Identification of single-point mutations in mycobacterial 16S rRNA sequences by confocal single-molecule fluorescence spectroscopy

We demonstrate the specific identification of single nucleotide polymorphism (SNP) responsible for rifampicin resistance of Mycobacterium tuberculosis applying fluorescently labeled DNA-hairpin structures (smart probes) in combination with single-molecule fluorescence spectroscopy. Smart probes are...

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Detalles Bibliográficos
Autores principales: Marmé, Nicole, Friedrich, Achim, Müller, Matthias, Nolte, Oliver, Wolfrum, Jürgen, Hoheisel, Jörg D., Sauer, Markus, Knemeyer, Jens-Peter
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2006
Materias:
Methods Online
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1540729/
https://www.ncbi.nlm.nih.gov/pubmed/16870719
http://dx.doi.org/10.1093/nar/gkl495

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1540729/
https://www.ncbi.nlm.nih.gov/pubmed/16870719
http://dx.doi.org/10.1093/nar/gkl495

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