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Identification of single-point mutations in mycobacterial 16S rRNA sequences by confocal single-molecule fluorescence spectroscopy
We demonstrate the specific identification of single nucleotide polymorphism (SNP) responsible for rifampicin resistance of Mycobacterium tuberculosis applying fluorescently labeled DNA-hairpin structures (smart probes) in combination with single-molecule fluorescence spectroscopy. Smart probes are...
Autores principales: | Marmé, Nicole, Friedrich, Achim, Müller, Matthias, Nolte, Oliver, Wolfrum, Jürgen, Hoheisel, Jörg D., Sauer, Markus, Knemeyer, Jens-Peter |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2006
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1540729/ https://www.ncbi.nlm.nih.gov/pubmed/16870719 http://dx.doi.org/10.1093/nar/gkl495 |
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