Is there a role for Notch signalling in human breast cancer?

Aberrant Notch signalling has been observed in several human cancers, including acute T-cell lymphoblastic leukaemia and cervical cancer, and is strongly implicated in tumourigenesis. Unregulated Notch signalling in the mouse mammary gland leads to tumour formation. These results raise the possibili...

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Detalles Bibliográficos
Autores principales: Brennan, Keith, Brown, Anthony MC
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2003
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC154142/
https://www.ncbi.nlm.nih.gov/pubmed/12631384
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author Brennan, Keith
Brown, Anthony MC
author_facet Brennan, Keith
Brown, Anthony MC
author_sort Brennan, Keith
collection PubMed
description Aberrant Notch signalling has been observed in several human cancers, including acute T-cell lymphoblastic leukaemia and cervical cancer, and is strongly implicated in tumourigenesis. Unregulated Notch signalling in the mouse mammary gland leads to tumour formation. These results raise the possibility that Notch signalling might play a role in human breast cancer. There are currently few reports that address this question directly and this appears to be an area worthy of further investigation.
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spelling pubmed-1541422003-05-06 Is there a role for Notch signalling in human breast cancer? Brennan, Keith Brown, Anthony MC Breast Cancer Res Review Aberrant Notch signalling has been observed in several human cancers, including acute T-cell lymphoblastic leukaemia and cervical cancer, and is strongly implicated in tumourigenesis. Unregulated Notch signalling in the mouse mammary gland leads to tumour formation. These results raise the possibility that Notch signalling might play a role in human breast cancer. There are currently few reports that address this question directly and this appears to be an area worthy of further investigation. BioMed Central 2003 2003-01-20 /pmc/articles/PMC154142/ /pubmed/12631384 Text en Copyright © 2003 BioMed Central Ltd
spellingShingle Review
Brennan, Keith
Brown, Anthony MC
Is there a role for Notch signalling in human breast cancer?
title Is there a role for Notch signalling in human breast cancer?
title_full Is there a role for Notch signalling in human breast cancer?
title_fullStr Is there a role for Notch signalling in human breast cancer?
title_full_unstemmed Is there a role for Notch signalling in human breast cancer?
title_short Is there a role for Notch signalling in human breast cancer?
title_sort is there a role for notch signalling in human breast cancer?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC154142/
https://www.ncbi.nlm.nih.gov/pubmed/12631384
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